文献类型：期刊文献

英文题名：Exploring The Medication Rules And The Mechanism of Action Of Core Drug Pair For Insomnia Based On Data Mining, Network Pharmacology, And Molecular Docking

作者：Guo, Wenlong[1]; Jiang, Huijuan[1]; Li, Yanrong[2]; Yang, Jinlong[1]; Chen, Yuchan[2]

第一作者：郭文龙

机构：[1] Department of Science Teaching, Gansu University of Chinese Medicine, Dingxi Campus, No.13 Yongding West Road, Anding District, Gansu Province, Dingxi, 743000, China; [2] Department of Medical Teaching, Gansu University of Chinese Medicine, Dingxi Campus, No.13 Yongding West Road, Anding District, Gansu Province, Dingxi, 743000, China

第一机构：甘肃中医药大学定西校区

年份：2024

外文期刊名：SSRN

收录：EI(收录号：20240130757)

语种：英文

外文关键词：Association rules - Medicine - Molecular modeling

摘要：BACKGROUND: This work aimed to further explore the medication rules of Chinese medicine in treating insomnia. METHODS: A total of 104 prescriptions were statistically analyzed. The association rule algorithm was applied to mine the core drug combinations, network pharmacology was applied to analyze the core drug combinations’ mechanism of action, and molecular docking was applied for validation.RESULTS: The most frequently used drugs in prescriptions for treating insomnia are Semen Ziziphi Spinosae, Radix Glycyrrhizae, Ginseng, and Indian Bread With Pine. The majority of the drugs utilized were those that supplementing drug, followed by drugs that heat-clearing, mind-caming, and drugs that exterior-releasing. These drugs have properties of warmth and coldness and flavors of sweetness, spiciness, and bitterness. They affect the meridians of the liver, lungs, spleen, kidneys, heart, and stomach. The association rules were applied to analyze the core drug combinations, which included Radix Astragali–Ginseng, Rhizoma Chuanxiong–Radix Glycyrrhizae, Seman Platycladi–Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae–Radix Glycyrrhizae, Radix Polygalae–Semen Ziziphi Spinosae, and Radix Astragali–Semen Ziziphi Spinosae. Network pharmacology was used to analyze the drug pair of Radix Polygalae–Semen Ziziphi Spinosae in the treatment of insomnia through the cAMP signaling pathway, which involved multiple components and targets. Molecular docking revealed that the drug pair components showed excellent binding to targets.CONCLUSION: Chinese medicine effectively treats insomnia by utilizing a combination of medications that target multi-ingredients, multi-targets, and multi-signaling pathways. ? 2024, The Authors. All rights reserved.