文献类型：期刊文献

英文题名：Exhaled Nitric Oxide Predicts Glucocorticoid Response in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

作者：Chen, Jiao[1];Li, Juanjuan[1];Wang, Wenbing[1];Wang, Fang[1];Yang, Quanfu[2]

第一作者：陈军;陈静;陈杰

通信作者：Yang, QF[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]First Peoples Hosp Tianshui, Dept Resp & Crit Care Med, Tianshui, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), First Peoples Hosp Tianshui, Dept Resp & Crit Care Med, Tianshui, Peoples R China.

年份：2026

卷号：2026-June

期号：232

外文期刊名：JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

收录：;Scopus(收录号：2-s2.0-105041215881);WOS:【SCI-EXPANDED(收录号:WOS:001794265700020)】；

语种：英文

外文关键词：Pulmonary Disease . J. Vis. Exp. (232); e70947

摘要：This retrospective study evaluated the clinical value of fractional exhaled nitric oxide in predicting glucocorticoid response in patients with acute exacerbations of chronic obstructive pulmonary disease. Based on the critical value of fractional exhaled nitric oxide (FeNO) levels >= 25 ppb at admission, patients were categorized into two groups: the high FeNO group (n = 61) and the low FeNO group (n = 61). All patients received standard basic treatment, which included inhaled corticosteroids (ICS), short-acting beta 2 receptor agonists (SABA), and short-acting anticholinergic drugs (SAMA). The treatment subgroup was administered additional systemic glucocorticoid therapy. The primary outcomes of this study were improvements in forced expiratory volume in 1 s (FEV1% pred) and the COPD Assessment Test (CAT) score. Secondary outcomes included changes in the duration of hospital stay and levels of exhaled nitric oxide. Baseline exhaled nitric oxide (FeNO) levels were positively correlated with blood eosinophil counts. In the high-level FeNO group, patients in the treatment group showed significant improvements in lung function, a reduction in the COPD Assessment Test (CAT) score, and lower exhaled nitric oxide levels compared with the control group. Conversely, in the low-level FeNO group, no significant differences were observed between the treatment and control subgroups. These findings indicate that baseline fractional exhaled nitric oxide can identify eosinophilic airway inflammation and predict responsiveness to glucocorticoid therapy, supporting personalized glucocorticoid treatment selection in acute exacerbations of chronic obstructive pulmonary disease. This retrospective study shows that baseline fractional exhaled nitric oxide identifies eosinophilic airway inflammation and predicts glucocorticoid response in acute exacerbations of chronic obstructive pulmonary disease, supporting personalized treatment and reducing hospital stay.