文献类型：期刊文献

中文题名：基于GPX4通路调控细胞铁死亡探讨中医“瘀证”与骨质疏松症的关系

英文题名：Exploration of the Relationship between TCM Stasis Syndrome and Osteoporosis Based on GPX4 Pathway Regulation of Cell Ferroptosis

作者：宋重东[1];蒋宜伟[1,2];麻永胜[1];周玉英[2];郝东昶[1];刘沛[1];杨洋[1]

第一作者：宋重东

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：40

期号：9

起止页码：33

中文期刊名：中医药信息

外文期刊名：Information on Traditional Chinese Medicine

基金：国家自然科学基金项目(82160916);兰州市科技计划项目(2021-1-95);甘肃中医药大学教学研究与改革立项项目(YBXM-29);甘肃中医药大学中医学一级学科“岐黄英才”导师专项基金项目(2021)。

语种：中文

中文关键词：细胞铁死亡;瘀证;骨质疏松症;中医药

外文关键词：Ferroptosis;Stasis syndrome;Osteoporosis;Traditional Chinese medicine

摘要：中医药在防治骨质疏松症中发挥着重要作用,多以“虚证”立论,然而“虚证”与“瘀证”联系紧密,在骨质疏松症的辨证中应当对“瘀证”同样重视。GPX4通路可抑制人体细胞铁死亡中关键物质细胞内活性氧堆积,并对细胞铁死亡引起的组织特异性消融起重要调控作用,是目前研究细胞铁死亡的主要方向。国内外学者针对此通路做了大量研究,笔者通过查阅相关文献对GPX4通路介导破骨细胞、成骨细胞铁死亡在骨质疏松症中的发病机制,以及中医“瘀证”理论与GPX4通路调控细胞铁死亡和骨质疏松症之间关系进行总结,发现GPX4通路调控下破骨细胞及成骨细胞的铁死亡可降低骨吸收和骨形成,对骨代谢平衡产生影响,进而导致骨质疏松症发生或加剧病情。“瘀证”理论指导下运用活血化瘀类方药可以干预GPX4通路调控细胞铁死亡,对“骨代谢稳态”产生积极影响。
Traditional Chinese medicine(TCM)plays an important role in the prevention and treatment of osteoporosis.TCM theory on this is mostly based on‘deficiency syndrome’.However,‘deficiency syndrome’is closely related to‘stasis syndrome’,and equal attention should be paid to“blood stasis syndrome”in the syndrome differentiation of osteoporosis.GPX4 pathway can inhibit the accumulation of intracellular reactive oxygen species,which is the key substance in human cell ferroptosis,plays an important regulatory role in tissue-specific ablation caused by cell ferroptosis,and is currently the main direction for studying cell ferroptosis.Scholars at home and abroad have done a lot of research on this pathway.The author reviewed the literature on the pathogenesis of GPX4 pathway-mediated osteoclast and osteoblast ferroptosis in osteoporosis,and summarized the relationship of TCM‘stasis syndrome’theory and GPX4 pathway regulation of cell ferroptosis with osteoporosis.It was found that ferroptosis of osteoclasts and osteoblasts under the regulation of GPX4 pathway can reduce bone resorption and bone formation,affecting the balance of bone metabolism,and leading to osteoporosis or aggravation of the disease.Under the guidance of the theory of‘stasis syndrome’,the use of blood-activating and stasis-resolving prescriptions can interfere with the GPX4 pathway and regulate cell ferroptosis,which has a positive impact on‘bone metabolism homeostasis’.