文献类型：期刊文献

中文题名：CDX2与胃上皮化生研究进展

英文题名：Research progress of CDX2 and gastric epithelial metaplasia

作者：薛增福[1];李群星[2];张正坤[2]

第一作者：薛增福

机构：[1]甘肃中医学院,730000;[2]甘肃中医学院附属酒泉市人民医院消化科,735000

第一机构：甘肃中医药大学

年份：2008

卷号：28

期号：3

起止页码：194

中文期刊名：国际消化病杂志

外文期刊名：International Journal of Digestive Diseases

收录：CSTPCD

语种：中文

中文关键词：CDX2;胃癌;肠化生;胃食管反流病;胃食管连接处

外文关键词：CDX2; Gastric Carcinoma; Intestinal Metaplasia; Gastroesophageal reflux disease; Gastro-oesophageal junction

摘要：此文介绍了果蝇同源异型框转录因子(CDX2)的结构与功能,CDX2转基因鼠及CDX2与胃癌、肠化生、胃食管连接处肠上皮化生等近几年的研究情况,分析了CDX2作为特异性的早期肠转录因子在肠化生早期表达的重要意义。而CDX2与胃癌预后是否有关,还需要进一步研究,其可能是早期肠型胃癌的进展标志。
We review the research on the structure and function of the caudal-related homeobox transcription factor 2 （CDX2）, CDX2-transgenic mice, gastric cancer, intestinal metaplasia and gastro-oesophageal junction（GEJ） in recent years. The significance of CDX2, which is a specific transcription factor in the early metaplasia is also discussed. But CDX2 as an early intestinal metaplasia signs, whether relation with the gastric carcinoma prognosis, still needs further study. However, it may be an early signs of intestinal advanced gastric cancer.