文献类型：期刊文献

中文题名：健胃清肠合剂对小鼠肠管运动及胃黏膜的影响

英文题名：Effect of JianWei QingChang Mixture on Intestinal Movement and Gastric Mucosa of Mice

作者：杨维建[1];李娟[2];张超[2];邓毅[2]

第一作者：杨维建

机构：[1]甘肃省中医院;[2]甘肃中医学院

第一机构：甘肃省中医院

年份：2012

卷号：25

期号：8

起止页码：20

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：甘肃省中医药管理局科研项目(编号GZK-2010-10)

语种：中文

中文关键词：健胃清肠合剂;药效学;肠蠕动;组织学;急性毒性

外文关键词：JianWei QingChang mixture; pharmacodynamics; intestinal peristalsis; histology; acute toxicity

摘要：目的:观察健胃清肠合剂对小鼠肠管运动及胃黏膜的影响。方法:采用炭末推进法观察健胃清肠合剂对小鼠肠管运动的作用;以该合剂高、中、低剂量组灌胃给药,分别观察小鼠排便状况及胃黏膜组织学变化;采用急性毒性实验观察小鼠半数致死量。结果:健胃清肠合剂各组均有增强小鼠肠蠕动作用,与甘露醇组比较有统计学意义(P<0.05);组织学观察各药物组未见明显的病理学改变;急性毒性实验小鼠致死量为13.95 g/kg。结论:健胃清肠合剂有明显促进小鼠肠管运动的作用,对胃黏膜无明显刺激作用,常规剂量用药安全。
Objective： To observe the effect ofJianWei QingChong mixture on intestinal movement and gastric mucosa. Method： Function ofJianWei QingChang mixture on intestinal movement of mice were observed with the pro- pelling method of carbo medicinalis; the state of bowel movement and histological changes of gastric mucosa in mice were explored respectively after intragastric administration of large, medium, low dose of mixture; median lethal dose （LD50） of mice were studied through acute toxicity experiment. Result： Intestinal peristalsis of mice increased in Jian- Wei QingChong mixture groups, it showed statistical meaning compared with mannitol group （P〈0.05）; no obvious pathological changes was seen in different groups; lethal dose were 13.95 g/kg in acute toxicity experiment. Conclu- sion： JianWei QingChang mixture can promote intestinal movement of mice remarkably and has no irritation to gastric mucosa, regular dose is safe.