文献类型：期刊文献

英文题名：New alpha, beta-unsaturated bis-enone derivatives: Anticancer activity in human osteogenic sarcoma cells and docking study

作者：Liu, Di[1];Shen, Rong[2];Zhao, Li-Xia[3];Hou, Chen-Chen[4];Cheng, Ju[5];Bai, De-Cheng[1]

第一作者：Liu, Di

通信作者：Bai, DC[1];Cheng, J[2]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Lanzhou Univ, Sch Basic Med Sci, Inst Human Anat & Tissue Embryol, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Nursing, Lanzhou, Gansu, Peoples R China;[4]Natl Drug Regulatory Authoritys, Drug Review Ctr, Beijing, Peoples R China;[5]Lanzhou Univ, Sch Basic Med Sci, Inst Operat Surg, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Inst Operat Surg, Lanzhou, Gansu, Peoples R China.

年份：2019

卷号：18

期号：4

起止页码：315

外文期刊名：MAIN GROUP CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000489045300001)】；

基金：This work was supported by grants from the Fundamental Research Funds for the Central Universities (No. lzujbky-2016-61).

语种：英文

外文关键词：Bis-enone; crystal structure; anticancer activity

摘要：Novel alpha, beta-unsaturated bis-enone derivatives (1-8) were designed and synthesized via a one pot organic synthesis method, which were further characterized by infrared radiation (IR) spectrum, H-1 nuclear magnetic resonance (NMR), high resolution mass spectrometer (HRMS), and single crystal X-ray crystallography. The anticancer activity of these compounds was investigated against four human osteogenic sarcoma cells (MG63, U2OS, 143B and OS -732) by 3-(4,5-dimethyl-thiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) assay. Furthermore, molecular docking study supported the biological assay data and suggested that compound 6 may be a potential anticancer agent.