文献类型：期刊文献

英文题名：Relationship between ferroptosis and mitophagy in acute lung injury: a mini-review

作者：Cheng, Yunhua[1,2];Zhu, Liling[3];Xie, Shuangxiong[1,2];Lu, Binyuan[1,2];Du, Xiaoyu[4];Ding, Guanjiang[1,2];Wang, Yan[1,2];Ma, Linchong[2];Li, Qingxin[2]

第一作者：Cheng, Yunhua

通信作者：Li, QX[1]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China;[2]940th Hosp Joint Logist Support Force Chinese Peop, Dept Thorac Surg, Lanzhou, Gansu, Peoples R China;[3]Hunan Childrens Hosp, Dept Anesthesiol, Changsha, Hunan, Peoples R China;[4]Northwest Minzu Univ, Med Coll, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), 940th Hosp Joint Logist Support Force Chinese Peop, Dept Thorac Surg, Lanzhou, Gansu, Peoples R China.

年份：2024

卷号：12

期号：9

外文期刊名：PEERJ

收录：;Scopus(收录号：2-s2.0-85203854641);WOS:【SCI-EXPANDED(收录号:WOS:001316376400003)】；

基金：This study was funded by the Research Project of the 940th Hospital of Joint Logistics Support Force of Chinese People's ' s Liberation Army (2023YXKY030) . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

语种：英文

外文关键词：Acute lung injury; Ferroptosis; Mitochondria; Mitophagy; Relationship; Mechanism

摘要：Acute lung injury (ALI) is one of the most deadly and prevalent diseases in the intensive care unit. Ferroptosis and mitophagy are pathological mechanisms of ALI. Ferroptosis aggravates ALI, whereas mitophagy regulates ALI. Ferroptosis and mitophagy are both closely related to reactive oxygen species (ROS). Mitophagy can regulate ferroptosis, but the specific relationship between ferroptosis and mitophagy is still unclear. This study summarizes previous research findings on ferroptosis and mitophagy, revealing their involvement in ALI. Examining the functions of mTOR and NLPR3 helps clarify the connection between ferroptosis and mitophagy in ALI, with the goal of establishing a theoretical foundation for potential therapeutic approaches in the future management of ALI.