文献类型：期刊文献

中文题名：基于指纹图谱和量值传递关系评价姜石颗粒关键生产工艺

英文题名：Evaluation on Key Production Process of Jiangshi Granules Based on Fingerprint and Quantity-Value Transfer Relationship

作者：张红伟[1];党文飞[1];周晶晶[1];周洁[1];靳子明[2];窦霞[2]

第一作者：张红伟

机构：[1]甘肃中医药大学药学院,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730020

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2024

卷号：31

期号：10

起止页码：135

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；

基金：国家自然科学基金(82360944);甘肃省科技厅科技重大专项-2022年中医药产业创新联合体项目(22ZD6FA021-4);兰州市城关区科学技术局课题(2021-2-9);甘肃省中医药科研重点课题(GZKP-2022-23);甘肃中医药大学附属医院院内创新基金项目(gzfy-2020-15)。

语种：中文

中文关键词：姜石颗粒;指纹图谱;生产工艺;含量测定;转移率;量值传递

外文关键词：Jiangshi Granules;fingerprint;production process;content determination;transport rate;value dissemination

摘要：目的基于指纹图谱和量值传递关系相结合模式,对姜石颗粒的关键生产工艺进行评价。方法采用HPLC建立姜石颗粒提取液、浸膏、颗粒的指纹图谱,以指纹图谱共有峰传递数、多成分含量转移率为指标,分析生产环节中量值传递规律,评价姜石颗粒制备工艺设计的合理性。结果建立了10批姜石颗粒提取液、浸膏、颗粒的指纹图谱,共标定17个共有峰并指认出8个峰,分别为党参苷Ⅰ、甘草苷、党参炔苷、芹糖异甘草苷、异甘草苷、甘草素、甘草酸、白术内酯Ⅲ;8个成分的饮片-提取液平均转移率分别为29.42%、51.26%、23.81%、34.45%、28.29%、30.22%、42.67%、26.10%,提取液-浸膏平均转移率分别为50.05%、60.04%、51.04%、50.27%、47.60%、52.44%、53.44%、44.97%,浸膏-颗粒平均转移率分别为64.83%、78.74%、70.16%、66.56%、70.62%、69.59%、76.97%、66.43%。结论本研究建立的姜石颗粒提取液、浸膏、颗粒指纹图谱稳定可靠,强调中药制剂研究过程的整体性,可为姜石颗粒在生产过程中的质量控制提供依据。
Objective To evaluate the key production process of Jiangshi Granules based on the new mode of combining fingerprint and quantity-value transfer relationship.Methods The fingerprints of Jiangshi Granules extract,extractum and granules were established by HPLC.The common peak transfer number of the fingerprint,the calculation of multi-component content transfer rate,and the paste rate were set as indicators to analyze the quantity and mass transfer law in the production process.The rationality of the preparation process design of Jiangshi Granules was evaluated.Results The fingerprints of 10 batches of Jiangshi Granules extract,extractum and granules were established.17 common peaks were calibrated and 8 peaks were identified.They were respectively tangshenoside I,liquiritin,lobetyolin,isoliquiritin apioside,isoliquiritin,liquiritigenin,glycyrrhizic acid,atractylenolideⅢ;the average transfer rates of 8 components from decoction pieces to extract were 29.42%,51.26%,23.81%,34.45%,28.29%,30.22%,42.67%,26.10%;the average transfer rates of extract to extractum were 50.05%,60.04%,51.04%,50.27%,47.60%,52.44%,53.44%,44.97%;the average transfer rates of extractum to granules were 64.83%,78.74%,70.16%,66.56%,70.62%,69.59%,76.97%,66.43%.Conclusion The established fingerprint of Jiangshi Granules extract,extractum and granules is stable and reliable,which emphasizes the integrity of the research process of TCM preparations and provides a basis for the quality control of Jiangshi Granules in the production process.