文献类型：期刊文献

中文题名：基于肺肠轴探讨肠道菌群在慢性阻塞性肺疾病作用机制研究进展

英文题名：Research Progress on the Mechanism of Gut Microbiota in COPD based on the Lung Gut Axis

作者：杨星星[1];郭晓颖[2];沈明霞[3];高永蕊[1];王静[1]

第一作者：杨星星

机构：[1]甘肃中医药大学,甘肃兰州730020;[2]兰州市城关区白银路街道社区卫生服务中心,甘肃兰州730000;[3]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2025

卷号：39

期号：10

起止页码：122

中文期刊名：实用中医内科杂志

外文期刊名：Journal of Practical Traditional Chinese Internal Medicine

基金：甘肃省自然科学基金项目(20JR10RA342);甘肃省中管局项目(GZKP-2022-44)。

语种：中文

中文关键词：肺肠轴;肠道菌群;慢性阻塞性肺疾病;作用机制;综述

外文关键词：lung intestinal axis;gut microbiota;chronic obstructive pulmonary disease;mechanism of action;overview

摘要：慢性阻塞性肺疾病是一种以气道炎症为核心且常伴有全身慢性炎症反应的疾病,肠道菌群是长期存在于人体肠道内的微生物群落,正常状态肠道菌群使得肠道黏膜屏障完整、影响人体的营养吸收、抵御病原体及调节免疫;肺部和肠道通过微生物及其代谢产物相互影响,肠道菌群失调,屏障功能受损,肠道通透性增加,俗称“肠漏”,促进微生物及代谢产物转移到体循环中并可能引发全身炎症反应,从而加剧呼吸系统病变。肠道微生物组在肠-肺轴中的重要作用,特别是在调节全身免疫反应方面,为治疗干预开辟了新的途径。
Chronic obstructive pulmonary disease is a disease with airway inflammation as its core and often accompanied by systemic chronic inflammatory response.The gut microbiota is a microbial community that exists in the human intestine for a long time.In a normal state,the gut microbiota makes the intestinal mucosal barrier intact,affects the body's nutrient absorption,resists pathogens,and regulates immunity;The lungs and intestines interact with each other through microorganisms and their metabolites,leading to dysbiosis of the gut microbiota,impaired barrier function,increased intestinal permeability,commonly known as"intestinal leakage",which promotes the transfer of microorganisms and metabolites into the systemic circulation and may trigger systemic inflammatory reactions,thereby exacerbating respiratory system diseases.The important role of the gut microbiome in the gut lung axis,particularly in regulating systemic immune responses,has opened up new avenues for therapeutic interventions.