文献类型：期刊文献

中文题名：舌下含服脱敏治疗小儿过敏性鼻炎的效果及对患儿免疫功能的影响

英文题名：Effect of sublingual desensitization on immune function in children with allergic rhinitis

作者：刘思强[1];马丽娜[1]

第一作者：刘思强

机构：[1]甘肃中医药大学

第一机构：甘肃中医药大学

年份：2019

卷号：16

期号：4

起止页码：30

中文期刊名：湖南师范大学学报：医学版

收录：CSTPCD

语种：中文

中文关键词：舌下含服;过敏性鼻炎;免疫功能;疗效

外文关键词：sublingual administration;allergic rhinitis;immune function;curative effect

摘要：目的:分析舌下含服脱敏治疗小儿过敏性鼻炎的效果及对患儿免疫功能的影响.方法:选取某院2015年1月~2018年1月收治的小儿过敏性鼻炎患儿124例,根据治疗方法不同分为对照组和观察组.对照组患儿采用常规治疗,观察组患儿采用舌下含服脱敏治疗,分析两组患儿治疗后的临床效果.结果:观察组患儿总有效率为95.16%,对照组为82.26%,观察组患儿总有效率高于对照组,差异有统计学意义.观察组患儿鼻痒、流涕、打喷嚏缓解时间短于对照组,差异有统计学意义.治疗前,两组患儿ICAM-1、VCAM-1、CRP、IL-12水平比较,差异无统计学意义.治疗后,观察组患儿IL-12水平高于对照组,ICAM-1、VCAM-1、CRP水平低于对照组,差异有统计学意义.治疗前,两组患儿免疫功能指标水平比较,差异无统计学意义.治疗后,观察组患儿CD3+、CD4+、CD4+/CD8+水平高于对照组,差异有统计学意义.结论:舌下含服脱敏治疗小儿过敏性鼻炎疗效显著,可降低ICAM-1、VCAM-1、CRP水平,提高免疫功能.
Objective To analyze the effect of sublingual desensitization on the immune function of children with allergic rhinitis.Methods 124 children with allergic rhinitis admitted in a hospital from January 2015 to January 2018 were divided into control group and observation group according to different treatment methods.The patients in the control group were treated with routine therapy,and the children in the observation group were treated with sublingual desensitization.Results The total effective rate of observation group was 95.16 and that of control group was 82.26.The total effective rate of observation group was higher than that of control group.The relieving time of nasal itch,runny and sneezing in the observation group was shorter than that in the control group.Before treatment,there was no significant difference in the level of IL-12 between the two groups(ICAM-1,VCAM-1,CRP).After treatment,the level of IL-12 in the observation group was higher than that in the control group and the level of VCAM-1 was lower than that in the control group,the difference was statistically significant.Before treatment,there was no significant difference in the level of immune function between the two groups.After treatment,the levels of CD3+,CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group.Conclusion The effect of sublingual desensitization on allergic rhinitis in children was significant,which could reduce the level of ICAM-1,VCAM-1,CRP and improve immune function.