文献类型：期刊文献

英文题名：Biological functions and molecular mechanisms of circHIPK3 in digestive system tumors

作者：Li, Jian[1,2];Su, Xin[1,2];Xu, Xiao[1,2];Ye, Youbao[1,2];Wang, Cailiu[1,2];Liu, Ang[1,2];Zhao, Changchun[1,2];Liu, Wenxiu[1,2];Yang, Liwen[1];Wang, Tao[3];Hao, Xiangyong[2]

第一作者：Li, Jian;李俊

通信作者：Hao, XY[1];Wang, T[2]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Dept Gen Surg, 204 Donggang West Rd, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730000, Peoples R China;[3]Gansu Prov Hosp, Dept Colorectal Surg, 204 Donggang West Rd, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Colorectal Surg, 204 Donggang West Rd, Lanzhou 730000, Peoples R China.

年份：2025

卷号：38

期号：4

外文期刊名：HUMAN CELL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001498667300001)】；

基金：The graphical is created with Figdraw and Flaticon.com.

语种：英文

外文关键词：CircHIPK3; Digestive system tumor; Molecular mechanism; Therapeutic target; Biomarker

摘要：Digestive system tumors are the most common tumors worldwide with high mortality rates. Circular homeodomain-interacting protein kinase 3 (circHIPK3) is a highly abundant and stable circular RNA and have garnered significant attention in the field of cancer research. This review systematically explores potential of circHIPK3 as a clinical biomarker, clinical significance in pharmacotherapy, and molecular mechanisms that regulate biological functions such as cell proliferation, survival, migration, invasion, epithelial-mesenchymal transition, metabolism and angiogenesis in digestive system tumors. Moreover, this review further explored the influence of circHIPK3 on key signaling pathways and the potential clinical value as a diagnostic biomarker and therapeutic target. By delving into the biological functions and molecular mechanisms of circHIPK3, this review aims to provide novel research directions and theoretical guidance for the identification of new therapeutic targets and the development of individualized treatment protocols for digestive system tumors.