文献类型：期刊文献

英文题名：Protective Activities of Cistanoside A on Alcohol Induced Hepatotoxicity in Mice

作者：Luo, Huiying[1,2];Zhao, Fenqin[1];Wang, Lijuan[1,2];Zhu, Lijuan[1,2]

第一作者：Luo, Huiying;罗慧英

通信作者：Luo, HY[1]

机构：[1]Gansu Coll Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]Key Lab Pharmacol & Toxicol Tradit Chinese Med Ga, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Coll Tradit Chinese Med, AV Dingxi 30, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2014

卷号：33

期号：5

起止页码：778

外文期刊名：LATIN AMERICAN JOURNAL OF PHARMACY

收录：;Scopus(收录号：2-s2.0-84902211379);WOS:【SCI-EXPANDED(收录号:WOS:000340156300011)】；

语种：英文

外文关键词：Alcohol; Cistanoside A; Energy metabolism; Free radical; Hepatoprotection

摘要：Cistanoside A (C.A) is a phenylethanol glycoside isolated from a Chinese traditional medicine named Cistanche deserticola. In a previous research we demonstrated that C. A presented protective activities on CCl4 induced hepatotoxicity in mice, the mechanism was involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respiratory chain function in mitochondria. Here, the effects of C. A on alcohol induced hepatotoxicity were evaluated in mice. Our research reveal that C. A (10, 20 mg/kg p.o. for 14 days) could significantly ameliorate the hepatic function indices (AST, ALT, ALP and LDH, P < 0.05) and decrease the levels of TG and TC in liver tissue. The biochemical results were also confirmed by histopathological examination, such as lightening steatosis and inflammatory infiltration, maintaining cell morphology complete and homogeneity. Meanwhile, C. A could increase the activities of mitochondrial antioxidant enzymes (GST, SOD, and CAT) and energy metabolism marker enzymes (total ATPases, Na+-K+-ATPase, Ca2+-Mg2+-ATPase, P < 0.05), decrease the contents of MDA and LPO, indicating that protective activities of C. A on alcohol induced hepatotoxicity in mice was involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and alleviating energy metabolism in mitochondria.