文献类型：期刊文献

中文题名：中药治疗溃疡性结肠炎口服与灌肠用药对比研究

英文题名：Contrastive Research on Differences of Oral and Enema Chinese Herbal Compounds in Treatment of Ulcerative Colitis

作者：柳春[1];李子荣[1];董亚丽[1];梁永林[1]

第一作者：柳春

机构：[1]甘肃中医药大学信息工程学院,甘肃兰州730000

第一机构：甘肃中医药大学信息工程学院（教育技术中心）

年份：2021

卷号：35

期号：1

起止页码：40

中文期刊名：实用中医内科杂志

外文期刊名：Journal of Practical Traditional Chinese Internal Medicine

基金：甘肃省科技计划(1610RJZA070);甘肃中医药大学中青年科研基金项目(2013-18099)。

语种：中文

中文关键词：中医学;溃疡性结肠炎;汤剂口服;汤剂灌肠;用药规律;对比分析;四气五味;归经

外文关键词：traditional Chinese medicine;ulcerative colitis;oral decoction;decoction for enema;laws of compatibility;contrastive analysis;four natures and five flavors;meridian tropism

摘要：目的探讨中药治疗溃疡性结肠炎(UC)汤剂口服与汤剂灌肠用药异同。方法检索近15年医学期刊发表的中药治疗UC临床疗效好的研究文献,提取元数据建立"UC方剂数据库",对口服与灌肠治疗用药的功效、性味、归经等因素进行χ^(2)或Fisher’s确切概率检验。结果口服方中核心药物有18味,分别是:甘草、黄连、木香、白术、白芍、黄芩、白头翁、当归、党参、地榆、黄芪、茯苓、陈皮、薏苡仁、干姜、败酱草、肉桂、山药,累计293味次,累计频率72.17%;灌肠方中核心药物有14味,分别是:白及、黄柏、黄连、地榆、白头翁、苦参、三七、五倍子、白芍、赤芍、秦皮、败酱草、甘草、当归,累计299味次,累计频率71.36%。口服药物以补虚药为主,辅以清热药、理气药;药性以寒、温、平为主;药味以苦、甘、辛为主;归经以脾、胃、大肠、肺、心经为主。灌肠药物以清热药、止血药为主;药性以寒为主;药味以苦、涩、甘为主;归经以大肠、肝、胃经为主。口服与灌肠用药功效、性味、归经均有统计学差异。结论中医治疗UC由于给药途径不同用药差异较大,口服药物重在补虚、清热、理气;灌肠药物重在清利湿热、和血止血。挖掘中医治疗UC用药规律时要区分给药途径,得到的规律才更符合临床实际,具有指导意义。
Objective To find out differences of oral and enema Chinese herbalcompounds(CHCs)in treatment of ulcerative colitis(UC)patients.Methods The CHCs for treating UC patients published in medical journals in recent 15 years were retrieved.The database of CHCs was set up.The core drugs’functions,properties,flavors and meridian tropism were statistically analyzed byχ^(2) or Fisher’s test between oral and enema compounds.Results The coredrugs for oral decoction were 18,including Gancao(Glycyrrhiza uralensis),Huanglian(Coptis chinensis),Muxiang(Aucklandia lappa),Baizhu(Atractylodes macrocephala),Baishao(Paeonia lactiflora),Huangqin(Scutellaria baicalensis),Baitouweng(Pycnonotus sinensis),Danggui(Angelica sinensis),Dangshen(Codonopsis pilosula),Diyu(Sanguisorba officinalis),Huangqi(Astragalus propinquus),Fuling(Poria cocos),Chenpi(Citrus reticulata),Yiyiren(Coix lacryma-jobi),Ganjiang(Zingiber oj-jicinale),Baijiangcao(Patrinia),Rougui(Cinnamomum cassia),Shanyao(Dioscorea oppositifolia),totally 293 times.The cumulative frequency was 72.17%.The decoction for enema had 14 drugs,including Baiji(Bletilla striata),Huangbai(Phellodendron chinense),Huanglian(Coptis chinensis),Diyu(Sanguisorba officinalis),Baituoweng(Pycnonotus sinensis),Kushen(Sophora flavescens),Sanqi(Panax notoginseng),Wubeizi(Rhus chinensis),Baishao(Paeonia lactiflora),Chishao(Paeonia),Qinpi(raxinus),Baijiangcao(Patrinia),Gancao(Glycyrrhiza uralensis),Danggui(Angelica sinensis),totally 299 times.The cumulative frequency was71.36%.In oral CHCs,Chinese medicinal drugs fortonifying,clearing heat and regulating Qi were identified as high frequency herbs.As for drugs properties,cold,warm and gentle properties occupied the top 3.As for flavors,bitter,sweetand acrid tastes occupied the top 3.From the meridian tropism aspect,spleen meridian,stomach meridian,large intestine meridian,lung meridian and heart meridian occupied the top 5.On the other hand,in enema CHCs,heat-clearing and bleeding-stopping drugshad high frequency.As for herbal properties,cold property played an important role.As for flavors,bitter,astringent and sweet tastes were very important.From the meridian tropism aspect,large intestine meridian,liver meridian and stomach meridian occupied the top 3.All of the four aspects had statistical significance between oral and enema CHCs.Conclusion The effect of traditional Chinese medicine treating UC depends on the route of administration.The oral administration pays attention to tonifying,clearing heat and regulating Qi.The enema administration focuses on clearing heat and dampness as well as harmonizing blood and stopping bleeding.The high frequency herbs obtained from analytical statistics could provide evidence for clinical medication.