文献类型：期刊文献

中文题名：从脾肾论治骨质疏松症的OPG/RANK/RANKL信号调控机制

英文题名：Discussion of OPG/RANK/RANKL signal-regulated mechanism of osteoporosis from the spleen and kidney theory

作者：赵希云[1];张晓刚[1,2];曹林忠[1];宋敏[1];张宏伟[1];秦大平[1];王振[1]

第一作者：赵希云

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院,兰州730020

第一机构：甘肃中医药大学

年份：2016

卷号：22

期号：9

起止页码：1206

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：国家自然科学基金项目(815607802)

语种：中文

中文关键词：中医中药;骨质疏松症;OPG/RANK/RANKL系统;脾肾同治;机制

外文关键词：Chinese Medicine; Osteoporosis; OPG/RANK/RANKL system; Simultaneous treatment of spleen and kidney; M echanism

摘要：中医处方遣药传承"辨证论治"之道,强调机体的整体性和时空性,但往往缺乏客观的分子生物学依据解释其作用机理;OPG/RANK/RANKL系统是骨代谢史上里程碑式的发现,对骨质疏松的中医药防治及研究开创新的纪元,从脾肾论治的效应最终可通过该系统对骨代谢调控的微观信息来表达,可以说OPG/RANKL/RANK系统是广大学者热衷于探究中药机理的切入点和共通点。基于此,本文就骨质疏松症的病因病机及治则方药结合OPG/RANK/RANKL系统对骨代谢的调控机制做一综述,旨在为原发性骨质疏松症的中医药防治提供客观的分子生物学依据。
The prescription of traditional Chinese medicine（TCM） inherits the theory of treatment based on syndrome differentiation,emphasizing integrity and temporality and spatiality of the whole body.However,it often lacks objective basis of molecular biology to explain its mechanism.OPG/RANK/RANKL system is a landmark discovery in the history of bone metabolism,which initiates a new era for the prevention,treatment,and research of osteoporosis with traditional Chinese medicine.The treatment effect based on spleen and kidney can be expressed through micro-information of the regulation in bone metabolism.OPG/RANKL/RANK system is the cut-off and common point for most of the scholars who are eager to explore the mechanism of traditional Chinese medicine.Based on this,this paper summarizes the etiology and pathogenesis of osteoporosis as well as the cure principles and medicines,combining with the regulatory mechanism of OPG/RANK/RANKL system in bone metabolism.It aims at providing objective evidence of molecular biology for the treatment and prevention of primary osteoporosis with Chinese medicine.