文献类型：期刊文献

中文题名：PI3K/Akt信号通路在少弱精子症中的作用及中医药调控研究进展

英文题名：Research progress on the role of PI3K/Akt signaling pathway in oligoasthenozoospermia and regulation by traditional Chinese medicine and pharmacy

作者：常家庆[1];赵威威[1];李启明[1];赵娟[1];王雪阳[1];鞠海超[1];杨佳树[1];邢喜平[2]

第一作者：常家庆

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]甘肃中医药大学附属医院男科,甘肃兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2025

卷号：22

期号：4

起止页码：66

中文期刊名：中国医药导报

外文期刊名：China Medical Herald

基金：甘肃省中医药科研课题(GZKP-2023-15)。

语种：中文

中文关键词：少弱精子症;PI3K/Akt信号通路;中医药;氧化应激

外文关键词：Oligoasthenozoospermia;PI3K/Akt signaling pathway;Traditional Chinese medicine and pharmacy;Oxidative stress

摘要：少弱精子症(OAS)是一种复杂难治的男科疾病,患者多无临床表现,但精液分析可见精子活力及浓度的异常。目前该病的发病机制尚未完全明确,但研究证实,PI3K/Akt信号通路在OAS的发生、发展中起重要作用,中医药在靶向调节PI3K/Akt信号通路治疗OAS中取得良好的效果。本文对PI3K/Akt信号通路在OAS中的作用及近年来中医药靶向调控PI3K/Akt信号通路防治OAS的研究进展进行综述,为临床诊疗OAS提供新的用药思路与选择。
Oligoasthenozoospermia(OAS)is a complex and difficult to treat male disease,patients often have no clinical manifestations,but semen analysis shows abnormalities in sperm motility and concentration.At present,pathogenesis of this disease is not fully understood,but research has confirmed that PI3K/Akt signaling pathway plays an important role in occurrence and development of OAS.Traditional Chinese medicine and pharmacy has achieved good results in targeted regulation of PI3K/Akt signaling pathway for the treatment of OAS.This article reviews the role of PI3K/Akt signaling pathway in OAS and research progress of targeted regulation of PI3K/Akt signaling pathway by traditional Chinese medicine and pharmacy in the prevention and treatment of OAS in recent years,providing new medication ideas and choices for clinical diagnosis and treatment of OAS.