文献类型：期刊文献

中文题名：骨碎补总黄酮防治原发性骨质疏松症的研究进展

英文题名：A survey of studies on the prevention and treatment of primary osteoporosis by total flavonoids of drynaria

作者：李建国[1];谢兴文[2,3];李晶[2,3];李宁[1];许伟[2,3];黄晋[2,3]

第一作者：李建国

机构：[1]甘肃中医药大学中医临床学院,兰州730000;[2]甘肃省中医院骨肿瘤科,兰州730050;[3]甘肃省中医药研究院骨伤病研究所,兰州730050

第一机构：甘肃中医药大学中医临床学院

年份：2019

卷号：39

期号：2

起止页码：229

中文期刊名：生命的化学

外文期刊名：Chemistry of Life

收录：CSTPCD;;CSCD:【CSCD_E2019_2020】；

基金：国家自然科学基金(地区)项目(81860864);兰州市科技局社会发展项目(2016-3-102);甘肃省属科研院所基础条件建设专项项目(18JR2TA016);国家中医药管理局中医临床研究基地业务建设专项项目(JDZX2015080);甘肃省省级引导科技创新发展专项资金项目;甘肃省卫健委十三五重点专科培育项目

语种：中文

中文关键词：骨碎补;总黄酮;骨质疏松

外文关键词：drynaria;total flavonoids;osteoporosis

摘要：骨质疏松症为常见的骨代谢疾病,随着社会老龄化加剧,其发病率亦逐年上升。近年来,传统中药防治骨质疏松症研究不断深入,研究发现,骨碎补及骨碎补总黄酮具有较明显的抗骨质疏松活性,能够通过有效地调节骨代谢及改善骨结构来发挥防治骨质疏松症的作用。本文从骨碎补总黄酮改善骨代谢及防治骨质疏松的细胞、动物、临床水平及相关通路研究进行综述,分析了目前研究概况及存在的问题,旨在为该药材防治骨质疏松症的深入研究及开发新的靶向治疗药物提供参考及借鉴。
Osteoporosis is a common bone metabolic disease.As the aggravation of social aging,its incidence rate is increasing year by year.In recent years,the traditional Chinese medicine prevention and treatment of loosening disease has been deepened,and it has been found that the flavonoids of Rhizoma Drynariae and its granules had obvious anti-osteoporosis activity,which could prevent osteoporosis by effectively regulating bone metabolism and improving bone structure.This article reviews the research on the cell,animal,clinical level and related pathways of bone granules to improve bone metabolism and prevent and treat osteoporosis,and analyzes the current research situation and existing problems.The aim of this work is to provide reference for the in-depth study of the medicinal materials for the prevention and treatment of osteoporosis and the development of new targeted therapeutic drugs.