文献类型：期刊文献

英文题名：The role of IL-38 in intestinal diseases - its potential as a therapeutic target

作者：Wang, Qiang[1];Ma, Linna[2];An, Caiping[3];Wise, Steven G.[4];Bao, Shisan[1]

第一作者：王强

通信作者：Bao, SS[1];An, CP[2]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Dept Anat, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med, Dept Pathol, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Hosp, Dept Haematol & Nephropathy, Lanzhou, Gansu, Peoples R China;[4]Univ Sydney, Fac Med & Hlth, Sch Med Sci, Sydney, NSW, Australia

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Basic Med, Dept Anat, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Haematol & Nephropathy, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85142143337);WOS:【SCI-EXPANDED(收录号:WOS:000886306800001)】；

基金：Funding Author SW is funded by a fellowship from the National Heart Foundation of Australia (105622).

语种：英文

外文关键词：IL-38; intestinal mucosa; immunity; inflammation; colorectal cancer

摘要：IL-38, an anti-inflammatory cytokine, is a key regulator of homeostasis in host immunity. Intestinal immunity plays a critical role in defence against pathogenic invasion, as it is the largest surface organ and the most common entry point for micro-organisms. Dysregulated IL-38 activity is observed in several autoimmune diseases including systemic lupus erythematosus and atherosclerosis. The protective role of IL-38 is well illustrated in experimental colitis models, showing significantly worse colitis in IL-38 deficient mice, compared to wildtype mice. Moreover, exogenous IL-38 has been shown to ameliorate experimental colitis. Surprisingly, upregulated IL-38 is detected in inflamed tissue from inflammatory bowel disease patients, consistent with increased circulating cytokine levels, demonstrating the complex nature of host immunity in vivo. However, colonic IL-38 is significantly reduced in malignant tissues from patients with colorectal cancer (CRC), compared to adjacent non-cancerous tissue. Additionally, IL-38 expression in CRC correlates with 5-year survival, tumour size and differentiation, suggesting IL-38 plays a protective role during the development of CRC. IL-38 is also an independent biomarker for the prognosis of CRC, offering useful information in the management of CRC. Taken together, these data demonstrate the role of IL-38 in the maintenance of normal intestinal mucosal homeostasis, but that dysregulation of IL-38 contributes to initiation of chronic inflammatory bowel disease (resulting from persistent local inflammation), and that IL-38 provides protection during the development of colorectal cancer. Such data provide useful information for the development of novel therapeutic targets in the management of intestinal diseases for more precise medicine.