文献类型：期刊文献

中文题名：小建中汤延缓老龄鼠胃衰老的实验研究

英文题名：Experimental Research on Anti-aging Effect of Xiaojianzhong Decoction on Rat Stomach

作者：张朝宁[1];潘虹[1];陈光顺[2];余臣祖[2]

第一作者：张朝宁

机构：[1]甘肃中医学院附属医院,甘肃兰州730000;[2]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2011

卷号：18

期号：6

起止页码：45

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2011_2012】；

基金：甘肃省教育厅科研项目(044B-07)

语种：中文

中文关键词：小建中汤;胃衰老;超氧化物歧化酶;丙二醛;脏器指数;大鼠

外文关键词：Xiaojianzhong decoction； stomach senility； SOD； MDA； organ index； rats

摘要：目的观察小建中汤的抗胃衰老作用。方法 45只老龄Wistar大鼠随机分为空白组、模型组、小建中汤组,每组15只。除空白组外,其余各组大鼠以10%D-半乳糖腹腔注射140 mg/(kg.d)造成衰老模型;小建中汤组每日予小建中汤水煎液灌胃。8周后检测各组大鼠血清总超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量,摘取大鼠胸腺、脾和胃称重并计算脏器指数。结果与模型组比较,小建中汤组脾、胃和胸腺的脏器指数增加,血清SOD活性升高,MDA含量降低。结论小建中汤具有抗氧化、清除自由基、修复胃黏膜损伤等作用,具有一定延缓胃衰老的作用。
Objective To observe the anti-aging effect on rat stomach of Xiaojianzhong decoction.Methods Forty-five rats were randomly divided into blank control group,model group,Xiaojianzhong decoction group.Aging models were induced by intraperitoneal injection of D-galactose 140 mg/（kg·d）to Wistar rats except for blank control group.After 8 weeks,SOD activity,MDA content in serum were detected.Spleen, stomach and thymus gland of rats were taken away and weighed,and their organ indices were calculated. Results Compared with model group,organ index of spleen,stomach and thymus gland of rats was increased,SOD activity in serum were significantly increased,MDA content in serum were significantly decreased in Xiaojianzhong decoction group.Conclusion Xiaojianzhong decoction can repair injured gastric mucosa,clean free radical,and possess good effect of antioxidation.It shows that Xiaojianzhong decoction can delay senility of stomach.