文献类型：期刊文献

英文题名：A polysaccharide-based micelle-hydrogel synergistic therapy system for diabetes and vascular diabetes complications treatment

作者：Wen, Na[1,4];Lu, Shaoyu[1];Xu, Xiubin[2];Ning, Piao[1];Wang, Zengqiang[1];Zhang, Zinan[1];Gao, Chunmei[1];Liu, Yongqi[3];Liu, Mingzhu[1]

第一作者：Wen, Na

通信作者：Lü, SY[1];Liu, MZ[1]

机构：[1]Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China;[2]Guangzhou Univ, Dept Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[4]Lanzhou City Univ, Sch Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China

第一机构：Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：100

起止页码：94

外文期刊名：MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;EI(收录号：20191006587822);Scopus(收录号：2-s2.0-85062287135);WOS:【SCI-EXPANDED(收录号:WOS:000466059700010)】；

基金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (grant no. 21875094, 51503091, 51541304, 51273086, 51603097), and the Fundamental Research Funds for the Central Universities (grant no. lzujbky-2018-82).

语种：英文

外文关键词：Micelle; Hydrogel; Glucose-responsive; Synergistic therapy; Thrombolysis

摘要：Various glucose-sensitive drug delivery platforms have been developed recently to treat diabetes. However, there is much less work has been reported on treatment of diabetes and vascular diabetes complications simultaneously. In this work, a novel polysaccharide-based micelle-hydrogel synergistic therapy system was fabricated to address this limitation. Zwitterionic dialdehyde starch-based micelles (SB-DAS-VPBA) were synthesized via single electron transfer-living radical polymerization (SET-LRP). Hydrophilic segment sulfobetaine (SB) and hydrophobic segment 4-vinylphenylboronic acid (VPBA) were grafted to the dialdehyde starch (DAS) backbones. Then, chitosan/dialdehyde starch derivatives (CS/SB-DAS-VPBA) micelle-hydrogel was synthesized by Schiff-base bonds. Insulin and nattokinase were loaded to obtain the micelle-hydrogel synergistic therapy system. In vitro drug delivery and blood clots dissolution behaviors were determined. Results suggest that the micelle-hydrogel synergistic therapy system not only possesses glucose-responsive insulin delivery property, but also provides good thrombolytic capacity. Thus, this micelle-hydrogel synergistic therapy system can be used as a platform for diabetes and vascular diabetes complications treatment.