文献类型：期刊文献

英文题名：Regulatory mechanisms and potential therapeutic targets in precancerous lesions of gastric cancer: A comprehensive review

作者：Zhang, Maofu[1];Zhong, Jialin[1];Song, Zhongyang[2];Xu, Qian[1];Chen, Yuchan[1];Zhang, Zhiming[3]

第一作者：Zhang, Maofu

通信作者：Zhang, ZM[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Oncol, Affiliated Hosp, Lanzhou 730020, Gansu, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Dept Oncol, Lanzhou 730050, Gansu, Peoples R China

第一机构：甘肃中医药大学中医临床学院

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Oncol, Lanzhou 730050, Gansu, Peoples R China.

年份：2024

卷号：177

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：;Scopus(收录号：2-s2.0-85198555011);WOS:【SCI-EXPANDED(收录号:WOS:001273647400001)】；

基金：This research was supported by the Major science and Technology Project of Gansu Province-Science and Technology Leading Talents Project (Grant No. 21ZDKA0014) ; Project of Cancer Clinical Medical Research Center of Integrated Traditional Chinese and Western Medicine of Gansu Province (Grant No.18JR2FA001, zxzl2021-8) ; Project supported by Gansu Science and Technology Program Fund (Key R&D Program) (Grant No. 22YF7FA) ; Key Laboratory of Diagnosis and Treatment of Gastrointestinal Tumors, National Health Commission (Grant No. NLDTG2020014) ; Major Science and Technology Project of Gansu Province (Grant No. Gan Keji [2022] 1-25) ; State Administration of Traditional Chinese Medicine Zhang Zhiming Studio construction project (Grant No. National Office of Traditional Chinese Medicine Teaching Letter [2022] No. 245) ; Innovation Project of Gansu Provincial Department of Education (Grant No.2022B-108) ; Traditional Chinese Medicine Research Project of Gansu Province (Grant No.G2KP-2021-15) ; Lanzhou Science and Technology Project (Grant No. 2023-2-49).r Project of Gansu Province-Science and Technology Leading Talents Project (Grant No. 21ZDKA0014) ; Project of Cancer Clinical Medical Research Center of Integrated Traditional Chinese and Western Medi-cine of Gansu Province (Grant No.18JR2FA001, zxzl2021-8) ; Project supported by Gansu Science and Technology Program Fund (Key R & D Program) (Grant No. 22YF7FA) ; Key Laboratory of Diagnosis and Treatment of Gastrointestinal Tumors, National Health Commission (Grant No. NLDTG2020014) ; Major Science and Technology Project of Gansu Province (Grant No. Gan Keji [2022] 1-25) ; State Administration of Traditional Chinese Medicine Zhang Zhiming Studio construction project (Grant No. National Office of Traditional Chinese Medicine Teaching Letter [2022] No. 245) ; Innovation Project of Gansu Provincial Department of Education (Grant No.2022B-108) ; Traditional Chinese Medicine Research Project of Gansu Province (Grant No.G2KP-2021-15) ; Lanzhou Science and Technology Project (Grant No. 2023-2-49) .

语种：英文

外文关键词：Gastric precancerous lesions (PLGC); Regulatory mechanisms; Molecular targets; Helicobacter pylori ( Hp )

摘要：Precancerous lesions of gastric cancer (PLGC) represent a critical pathological stage in the transformation from normal gastric mucosa to gastric cancer (GC). The global incidence of PLGC has been rising over the past few decades, with a trend towards younger onset ages. Increasing evidence suggests that early prevention and treatment of PLGC can effectively reverse the malignant development of gastric mucosal epithelial cells. However, there is currently a lack of effective therapeutic drugs and methods. Recent years have witnessed substantial advancements in PLGC research, with the elucidation of novel regulatory mechanisms offering promising avenues for clinical intervention and drug development. This review aims to delineate potential targets for early prevention and diagnosis of GC while exploring innovative approaches to PLGC management. This article focuses on elucidating the regulatory mechanisms of the inflammatory microenvironment, bile acids (BA), glycolysis, autophagy, apoptosis, ferroptosis, and cellular senescence. We pay particular attention to potential therapeutic targets for PLGC, with the goal of providing insights and theoretical basis for clinical research on PLGC.