文献类型：期刊文献

英文题名：Association between hypothyroidism and nephrotic syndrome: a bidirectional two-sample Mendelian randomization analysis

作者：Liu, Can[1];Shen, Jiaxuan[2];Ding, Zhaoran[1];Duan, Shuwen[1];Dai, Enlai[1,3]

第一作者：柳春

通信作者：Dai, EL[1]

机构：[1]Gansu Univ Chinese Med, Coll Integrat Med, Lanzhou 730030, Gansu, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Hand Surg Dept, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Dept Nephrol, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Integrat Med, Lanzhou 730030, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：46

期号：2

外文期刊名：RENAL FAILURE

收录：;Scopus(收录号：2-s2.0-85201321944);WOS:【SCI-EXPANDED(收录号:WOS:001292200700001)】；

基金：This research was funded by the National Natural Science Foundation of China (82160852) and the Gansu Province "Innovation Star" Fund of the Department of Education (2023CXZX-738). DAS:The summary data for NS can be downloaded from the website https://gwas.mrcieu.ac.uk/datasets/ebi-a-GCST90018884/with ID number GCST90018884, and the summary data for hypothyroidism can be downloaded from the website https://gwas.mrcieu.ac.uk/datasets/ebi-a-GCST90018862/with ID number GCST90018862. The first author can provide summary data that were used and/or analyzed for this study upon reasonable request.

语种：英文

外文关键词：hypothyroidism; nephrotic syndrome; Mendelian randomization; genome-wide association study

摘要：Background: There is a close clinical association between hypothyroidism and nephrotic syndrome (NS) was close, but whether there is genetic causality between the two is not known. Objective: Using pooled data from a genome-wide association study (GWAS), the association between hypothyroidism and NS was explored via Mendelian randomization (MR) analysis. Methods: Single-nucleotide polymorphisms (SNPs) associated with hypothyroidism (or NS) were screened as genetic instrumental variables (IVs) from pooled GWAS data, and inverse-variance weighting (IVW) was used for the main analysis to estimate causal effects, with MR-Egger, weighted median, and weighted mode used as complementary methods. Sensitivity analyses, including Cochran's Q test, MR-Egger intercept, MR-PRESSO and leave-one-out, were also conducted to assess the robustness of the results. Results: Genetically predicted hypothyroidism was positively associated with the risk of developing NS (IVW: OR = 1.18, 95% CI: 1.07-1.30, p = 0.00; MR-Egger: OR = 1.36, 95% CI: 1.10-1.68, p = 0.01), and the MR-Egger intercept (intercept = -0.02, p = 0.14), MR-PRESSO test (p = 0.14), Cochran's Q test (p = 0.15) and leave-one-out test results supported the robustness of the results. Genetically predicted NS status might not be associated with an increased risk of developing hypothyroidism (IVW: OR = 1.01, 95% CI: 1.00-1.03, p = 0.08; MR-Egger: OR = 1.01, 95% CI: 0.98-1.04, p = 0.43), and the MR-Egger intercept (intercept < 0.01, p = 0.69), MR-PRESSO test (p = 0.64), Cochran's Q test (p = 0.61) and leave-one-out test results supported the robustness of the results. Conclusion: Hypothyroidism status could increase the risk of developing NS.