文献类型：期刊文献

中文题名：中医药防治急性肺损伤作用机制研究进展

英文题名：Research Progress of TCM in Prevention and Treatment of ALI

作者：李赋[1];张志明[2];宋忠阳[3];雍文兴[3];朱鹏[1];吴亚娜[1];冯周利[1];赵海宏[1]

第一作者：李赋

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中医院,甘肃兰州730000;[3]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：39

期号：10

起止页码：80

中文期刊名：中医药信息

外文期刊名：Information on Traditional Chinese Medicine

基金：甘肃省科技重大专项(甘科计〔2022〕1号-25);高端人才承担省级科技计划项目(“长江学者奖励计划”)(甘科计〔2021〕20号-9);甘肃省中医药管理局课题(GZKP-2021-15);甘肃省中医药管理局中医药科研重点课题(GZKP-2020-8);甘肃省兰州市人才创新创业项目(2020-XG-29)。

语种：中文

中文关键词：中药;急性肺损伤;作用机制;研究进展

外文关键词：Chinese medicinal;Acute lung injury;Action mechanism;Research progress

摘要：急性肺损伤是一种临床常见急危重症,具有高发病率与高病死率的特点,至今尚缺乏有效治疗药物。近年来研究表明,中医药在防治急性肺损伤方面具有副作用小、多靶显效的独特优势,其具体作用机制仍在不断深入研究。笔者查阅相关文献,从抑制炎症反应、调节免疫功能、改善凝血障碍、调节水通道蛋白、诱导自噬缓解、改善氧化应激、调节细胞凋亡等方面阐述中医药防治急性肺损伤的作用机制,发现中医药干预能够显著调节肺损伤状态,减轻炎症损伤,并有效改善预后。
Acute lung injury(ALI),as a common clinical urgency and critical illness,has a high incidence and high mortality,and it still lacks of effective therapeutic drugs.In recent years,studies have shown that TCM has small side effects in preventing and treating ALI,and it also has unique advantages in significant multi-target effects.The study on specific mechanism of specific effects is still ongoing.The author mainly expounds the mechanism of TCM in preventing and treating ALI from the aspects of suppressing inflammatory response,regulating immune function,improving coagulation disorders,regulating water channel protein,inducing autophagy remission,improving oxidation stress and regulating cell apoptosis by reviewing relevant literature.It is found that TCM intervention can significantly adjust the state of lung injury,reduce inflammation damage,and effectively improve prognosis of the disease.