文献类型：期刊文献

英文题名：Development and evaluation of a new gastroretentive drug delivery system: Nanomicelles-loaded floating mucoadhesive beads

作者：Chen, Nana[1];Niu, Jing'e[1];Li, Qian[1];Li, Jianyin[1];Chen, Xinping[1];Ren, Yuan[1];Wu, Guotai[2];Liu, Yingqian[1];Shi, Yanbin[1]

第一作者：Chen, Nana

通信作者：Shi, YB[1]

机构：[1]Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Key Lab TCM Pharmacol & Toxicol Gansu Prov, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：51

起止页码：485

外文期刊名：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

收录：;Scopus(收录号：2-s2.0-85063645430);WOS:【SCI-EXPANDED(收录号:WOS:000468750300049)】；

基金：This work was supported by the Fundamental Research Funds for the Central Universities, Lanzhou University [grant number 863049]; Key Laboratory of TCM Pharmacology and Toxicology of Gansu Province [grant number ZDSYS-KJ-2016-001]; and The National Natural Science Foundation of China [grant number 21672092, 21877056].

语种：英文

外文关键词：Nanomicelles; Floating ability; Mucoadhesion; Gastroretention; Cytotoxicity

摘要：To better treat gastric diseases and lower systemic side effect, it is essential to design new vectors to control drug release in stomach. Aiming to this challenge, we developed a new gastroretentive drug delivery system: nanomicelles-loaded gastroretentive beads. Firstly, the chitosan-coated emodin-loaded nanomicelles were developed and characterized. In vitro cytotoxicity of emodin-loaded nanomicelles, emodin suspensions and blank nanomicelles was evaluated with human gastric carcinoma SGC-7901 cells by MTT, indicating that the blank nanomicelles had null cytotoxicity and emodin-loaded nanomicelles had better antitumor efficacy compared with emodin suspensions. Secondly, nanomicelles-loaded floating mucoadhesive beads (NFM-Beads) were prepared, and the swelling, degradation, mucoadhesion and floating ability in vitro were separately investigated. FT-IR spectroscopy was applied to identify the formation of nanomicelles and NFM-Beads. Emodin release from NFM-Beads in vitro was fitted to anomalous transport mechanism. In vivo gastroretention behavior of NFM-Beads was evaluated by BaSO4-based X-ray imaging exams, showing that NFM-Beads can be retained in rabbit stomach for at least 8 h. Overall, the new NFM-Beads system could be an effective approach to improve the therapeutic potency of drug against gastric cancer.