文献类型：期刊文献

中文题名：针药并用对变应性鼻炎患者肺通气功能、IFN-y水平及睡眠质量的影响

英文题名：Effect of acupuncture plus medication on the pulmonary ventilation, IFN-y level and sleep quality in allergic rhinitis patients

作者：雒海燕[1];魏清琳[1];田永萍[1];刘翔毅[2];王雅楠[3];张海[3]

第一作者：Luo Hai-yan

机构：[1]Acupuncture Clinical Center,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,China;[2]Basic Medical College,Gansu University of Chinese Medicine,Lanzhou 730020,China;[3]Zhangye People's Hospital Affiliated to Hexi University,Zhangye 734000,China

第一机构：Acupuncture Clinical Center,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,China

年份：2019

卷号：17

期号：6

起止页码：402

中文期刊名：Journal of Acupuncture and Tuina Science

外文期刊名：针灸推拿医学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；

语种：中文

中文关键词：针刺疗法;针药并用;鼻炎,变应性;丙酸氟替卡松;喷鼻剂;肺通气;干扰素;睡眠

外文关键词：Acup uncture Therapy;Acup uncture Medication Combi ned;Rhin itis;Allergic;Fluticas one Propi on ate;Nasal Sprays;Pulm on ary Ventilati on;In terfero ns;Sleep

摘要：目的:观察温通针法联合丙酸氟替卡松鼻喷雾剂对变应性鼻炎(AR)患者肺通气功能、V-干扰素(IFN?y)水平及睡眠质量的影响。方法:选取2013年1月至2018年8月就诊的112例AR患者,依据随机数字表法分为观察组和对照组,每组56例。观察组患者接受温通针法联合丙酸氟替卡松鼻喷雾剂治疗,对照组患者仅接受与观察组相同的丙酸氟替卡松鼻喷雾剂治疗。比较两组鼻部症状评分、肺功能指标、血清IFN*与白细胞介素(IL)-4水平以及睡眠质量情况。结果:治疗后,观察组总有效率高于对照组(PV0.05);两组鼻部症状评分均低于治疗前(均PV0.05),且观察组评分低于对照组(PV0.05);观察组肺功能各项指标均较治疗前明显上升(均PV0.05),对照组第一秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)、用力呼出50%、75%及25%~75%肺活量的呼气流速占预计值的百分比(FEF50%,FEF75%,FEF25%-75%)较治疗前上升(均P<0.05),且观察组肺功能各项指标均明显高于对照组(均PV0.05);两MIFN-y水平均较治疗前明显升高(均PV0.05), IL-4水平明显降低(均PV0.05),且观察组IFN*水平高于对照组(PV0.05), IL-4水平低于对照组(PV0.05);两组匹兹堡睡眠质量指数(PSQI)中睡眠质量评分、睡眠效率评分、睡眠障碍评分及PSQI总分均较治疗前明显降低(均PV0.05),且观察组各项评分明显低于对照组(均PV0.05)。结论:温通针法联合丙酸氟替卡松鼻喷雾剂治疗AR在控制临床症状与改善肺功能方面效果可靠,可改变患者的IFN-y和IL-4水平,使之接近正常范围;同时可改善患者睡眠,其效果优于单独使用丙酸氟替卡松鼻喷雾剂。
Objective:To observe the effect of warm-unblocking acupuncture plus fluticasone propionate nasal spray on the pulmonary ventilation,level of interferon-y(IFN-y)and sleep quality in parents with allergic rhinitis(AR).Methods:A total of 112 AR patients were enrolled between January 2013 and August 2018 and were divided into an observation group and a control group by the random number table method,with 56 cases in each group.Patients in the observation group received warm-unblocking acupuncture plus fluticasone propionate nasal spray,and patients in the control group only received fluticasone propionate nasal spray.The nasal symptom score,pulmonary function indexes,the levels of IFN-y and interleukin(IL)-4 in serum,and sleep quality in the two groups were compared.Results:After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The nasal symptom score dropped in both groups after treatment(both P<0.05),and the score in the observation group was lower than that in the con trol group(P<0.05).The pulm onary ven tilati on indexes all in creased sign ificantly after treatment in the observation group(all P<0.05);the forced expiratory volume in 1 second(FEV1)to forced vital capacity(FVC)ratio(FEV1/FVC)and the forced expiratory flow at 50%,75%and 25%-75%of the vital capacity(FEF50%,FEF75%,FEF25%-75%)in creased after treatme nt in the control group(all P<0.05);the pulm onary ven tilati on in dexes were higher in the observati on group tha n those in the control group(all P<0.05).The level of IFN-y in creased sign ificantly after t reatment in the two groups(both P<0.05)and the level of IL-4 dropped significantly(both P<0.05);the observation group had a higher IFN-y level(P<0.05)and a lower IL-4 level(P<0.05)compared with the control group.Regarding the Pittsburgh sleep quality index(PSQI),the scores of subjective sleep quality,habitual sleep efficiency and sleep disturbances and the general PSQI score decreased significantly after treatment in both groups(all P<0.05),and the scores in the observation group were significantly lower than those in the control group(all P<0.05).Conclusion:Warm-unblocking acupuncture plus fluticasone propionate nasal spray can effectively control the clinical symptoms and improve pulmonary function in the treatment of AR;this approach can regulate the levels of IFN-y and IL-4 towards the normal range in AR patients;it can also improve patient's sleep quality.This method can produce more significant efficacy than fluticasone propionate nasal spray used alone.