文献类型：期刊文献

英文题名：YKL-39 is an independent prognostic factor in gastric adenocarcinoma and is associated with tumor-associated macrophage infiltration and angiogenesis

作者：Xue, Ling[1,2];Chu, Wei[1];Wan, Fangsheng[1];Wu, Pingfan[1,2];Zhao, Xiaowen[1,2];Ma, Linna[1];She, Yali[3,4];Li, Changtian[1];Li, Yaling[1,3,4]

第一作者：薛莉;Xue, Ling

通信作者：Li, CT[1];Li, YL[1];Li, YL[2];Li, YL[3]

机构：[1]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[2]940th Hosp Joint Logist Support Peoples Liberat A, Dept Pathol, Lanzhou 730050, Peoples R China;[3]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Study Prevent & Treatment Tradit Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Study Prevent & Treatment Tradit Chinese Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;

年份：2022

卷号：20

期号：1

外文期刊名：WORLD JOURNAL OF SURGICAL ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85141665018);WOS:【SCI-EXPANDED(收录号:WOS:000882812600002)】；

基金：This work was supported by the Colleges and Universities Innovation Ability Improvement Project of Gansu Province, China (No. 2021B-166); Double first-class scientific research key projects in Gansu Province (No. GSSYLXM-21); Foundation of Key Laboratory of Dunhuang Medicine and Transformation Constructed by Chinese Ministry of Education and Gansu Province (No. DHYX20-07); and Scientific Research and Innovation Fund of Gansu University of Traditional Chinese Medicine (2020KCYB-9).

语种：英文

外文关键词：Gastric cancer; Tumor-associated macrophage; Tumor angiogenic; Prognosis

摘要：Background Gastric cancer has a high incidence and mortality rate. Angiogenesis is necessary for tumor infiltration and metastasis and affects patient prognosis. YKL-39 has monocyte chemotactic activity and pro-angiogenic activity in some tumors. In this study, we investigated the relationship between YKL-39 and tumor-associated macrophages and microangiogenesis in gastric cancer to determine its potential as a prognostic biomarker. Materials and methods A total of 119 patients with gastric cancer who had undergone gastrectomy at the 940th Hospital of the Joint Security Force between 2014 and 2018 were included in this study. We assayed the protein expression of YKL-39, CD68, and CD34 by immunohistochemistry in tissues of 119 patients with gastric cancer, as well as the intracellular expression of YKL-39 and CD68 by immunofluorescence. Data were analyzed with SPSS Statistics 25.0 to explore the impact of expression of YKL-39, CD68, and CD34 in gastric cancer patients and the relationship among them. Results Our results show that YKL-39 was expressed in both the nucleus and cytoplasm of gastric cancer cells and tumor mesenchyme. YKL-39 protein expression was associated with the depth of tumor infiltration, lymph node metastasis, and TNM stage; CD68 protein expression was associated with lymph node metastasis and TNM stage; CD34 protein expression was not associated with clinicopathological characteristics. Expression of YKL-39 was positively correlated with CD68 and CD34 (p < 0.001), and high expression of YKL-39 was associated with poor prognosis (p < 0.05). Conclusion In gastric cancer, YKL-39 expression is positively correlated with the degree of tumor-associated macrophage infiltration and angiogenesis, and is a potential prognostic marker for gastric cancer.