文献类型：期刊文献

英文题名：Non-histone Methylation of SET7/9 and its Biological Functions

作者：Gao, Lili[1];Yu, Weiping[2];Song, Peng[3,4];Li, Qing[1]

第一作者：Gao, Lili

通信作者：Li, Q[1];Song, P[2]

机构：[1]Pudong New Area Peoples Hosp, Dept Pathol, Shanghai 201299, Peoples R China;[2]Southeast Univ, Dept Pathophysiol, Med Sch, Nanjing 210009, Jiangsu, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China;[4]Key Lab Prevent & Treatment Chron Dis TCM, Lanzhou 730000, Gansu, Peoples R China

第一机构：Pudong New Area Peoples Hosp, Dept Pathol, Shanghai 201299, Peoples R China

通信机构：[1]corresponding author), Pudong New Area Peoples Hosp, Dept Pathol, Shanghai 201299, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2022

卷号：17

期号：3

起止页码：231

外文期刊名：RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY

收录：;Scopus(收录号：2-s2.0-85132821680);WOS:【SCI-EXPANDED(收录号:WOS:000877328000002)】；

基金：This work was supported by the National Natural Science Foundation of China (81803779), the Gansu Province Science Foundation for Distinguished Young Scholars (20JR10RA348), the Important Weak Subject Construction Project of Pudong Health and Family Planning Commission of Shanghai (PWZbr 2017-22) and the Pudong New Area Science and Technology Development Fund of Shanghai (PKJ2020-Y40) and the Innovation Fund Project of Affiliated Hospital of Gansu University of Chinese Medicine (gzfy-2020-8).

语种：英文

外文关键词：SET7/9; lysine methyltransferase; non-histone protein; methylation; tumorigenesis; teratoma

摘要：Background: (su(var)-3-9,enhancer-of-zeste,trithorax) domain-containing protein 7/9 (SET7/9) is a member of the protein lysine methyltransferases (PLMTs or PKMTs) family. It contains a SET domain. Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3 (H3-K4) and lysine(s) of non-histone proteins, including transcription factors, tumor suppressors, and membrane-associated receptors. Objectives: This article mainly reviews the non-histone methylation effects of SET7/9 and its functions in tumorigenesis and development. Methods: PubMed was screened for this information. Results: SET7/9 plays a key regulatory role in various biological processes such as cell proliferation, transcription regulation, cell cycle, protein stability, cardiac morphogenesis, and development. In addition, SET7/9 is involved in the pathogenesis of hair loss, breast cancer progression, human carotid plaque atherosclerosis, chronic kidney disease, diabetes, obesity, ovarian cancer, prostate cancer, hepatocellular carcinoma, and pulmonary fibrosis. Conclusion: SET7/9 is an important methyltransferase, which can catalyze the methylation of a variety of proteins. Its substrates are closely related to the occurrence and development of tumors.