文献类型：期刊文献

中文题名：中药多糖降脂作用机理的研究进展

英文题名：Research Progress on Lipid-Lowering Effect of Polysaccharides from Traditional Chinese Medicine and Its Mechanism

作者：代云云[1,2];谢晓蓉[1];王鹏波[1,2];刘建飞[2];孙艳艳[1,2];邸多隆[1,2]

第一作者：代云云

机构：[1]甘肃中医药大学药学院,兰州730000;[2]中国科学院兰州化学物理研究所中国科学院西北特色植物资源化学重点实验室和甘肃省天然药物重点实验室,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2021

卷号：37

期号：5

起止页码：219

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：甘肃省重大研发项目(编号:18YF1NA085);甘肃省教育厅成果转化项目(编号:2017D-16);宁夏回族自治区重点研发计划重大重点项目(编号:2019BEF02006)。

语种：中文

中文关键词：中药多糖;降血脂;药理活性;作用机制

外文关键词：polysaccharide in traditional Chinese medicine;lipid-lowering effect;pharmacological activity;mechanism

摘要：糖类化合物(单糖、寡糖和多糖)是自然界生物体内存在最广泛的物质之一,与核酸、蛋白质、脂质等构成生命活动的基本物质。多糖类成分是中药中重要的有效物质,已在免疫调节、抗病毒、抗肿瘤、抗辐射、抗衰老和降血脂等方面展示出显著的药理活性。近年来,中药多糖降血脂作用的研究引起国内外学者高度关注并取得重要进展。本文综述了近年来国内外对中药多糖降血脂作用机制的研究进展,并对中药多糖应用于高血脂治疗的前景进行了展望,以期为进一步开发以中药多糖为来源的中药新药提供参考。
Carbohydrates(monosaccharide,oligosaccharide and polysaccharide)are one of the most widely existed substances in organisms in nature,which constitute the basic substances of the life activities with nucleic acids,proteins,and lipids.Polysaccharides are important effective substances in traditional Chinese medicine,which have shown remarkable pharmacological activities,including immune regulation,antiviral,anti-tumor,anti-radiation,anti-aging and lipid lowering effect.In recent years,the lipid-lowering effect of polysaccharides from traditional Chinese medicine has attracted a great attention and interest of domestic and foreign scholars and some important progress has been made.This paper reviewed the research progress on the lipid-lowering effect of polysaccharides from traditional Chinese medicine and its mechanism in recent years,so as to provide reference for the further development of new drugs from traditional Chinese medicine polysaccharides.