文献类型：期刊文献

英文题名：Quercetin suppresses glomerulosclerosis and TGF-β signaling in a rat model

作者：Liu, Yifan[1];Dai, Enlai[1];Yang, Jing[2]

第一作者：刘艳峰

通信作者：Dai, EL[1]

机构：[1]Gansu Univ Chinese Med, Cooperat Chinese & Western Med Dept, 10 East Dingxi Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Hosp 2, Dept Children Glomerular Dis, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Cooperat Chinese & Western Med Dept, 10 East Dingxi Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2019

卷号：19

期号：6

起止页码：4589

外文期刊名：MOLECULAR MEDICINE REPORTS

收录：;Scopus(收录号：2-s2.0-85066127969);WOS:【SCI-EXPANDED(收录号:WOS:000474874600008)】；

基金：This work was supported by grants from the National Natural Science Foundation of China (grant no. 81360602), and the Science and Technology Development Project of Chengguan District, Gansu, Lanzhou (grant no. 2016-1-8).

语种：英文

外文关键词：quercetin; glomerulosclerosis; transforming growth factor-beta signaling pathway

摘要：The transforming growth factor-beta (TGF-beta) signaling pathway is an important regulatory pathway in renal fibrosis and is abnormally activated in glomerulosclerosis. Quercetin is a common Chinese herbal medicine and has been reported to inhibit TGF-beta signaling pathway activation. In the present study a glomerulosclerosis rat model was constructed and mice were treated with different concentrations of quercetin. Biochemical parameters, pathological indices and expression levels of TGF-beta signaling pathway-associated proteins were detected using immunohistochemistry and western blotting. It was demonstrated that quercetin significantly improved physiological indices and altered the expression levels of TGF-beta signaling pathway-associated proteins in rats with glomerulosclerosis. In conclusion, quercetin can regulate the TGF-beta signaling pathway and reduce the progression of glomerulosclerosis.