文献类型：期刊文献

英文题名：Percutaneous endoscopic decompression for lumbar spinal stenosis Protocol for a systematic review and network meta-analysis

作者：Liu, Jianjun[1];Zhang, Hongwei[1,2];Zhang, Xiaogang[1];He, Tao[3];Zhao, Xiyun[1];Wang, Zhipeng[1]

第一作者：刘建军

通信作者：Wang, ZP[1]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, 732 Jiayuguan West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Clin Coll Chinese Med, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Rehabil Cent Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, 732 Jiayuguan West Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2019

卷号：98

期号：20

起止页码：e15635

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85066853382);WOS:【SCI-EXPANDED(收录号:WOS:000473676000050)】；

基金：This work was supported by Gansu administration of traditional Chinese medicine project grant number GZK-2016-44 and National natural science foundation of China grant number 81560780.

语种：英文

外文关键词：lumbar spinal stenosis; network meta-analysis; percutaneous endoscopic decompression; systematic review

摘要：Background: Lumbar spinal stenosis (LSS) is a common and frequently-occurring disease in clinical practice. There are many interventions to treat it, and percutaneous endoscopic decompression (PED) is one of them, but their relative efficacy and safety remains unclear. Hence, the present study aims to synthesize the available direct and indirect evidence on the PED and other treatments for LSS. Methods: The following databases will be searched: Cochrane Library, PubMed, Web of Science, Embase and China Biomedical Literature Database (CBM). The search dates will be set from the inception to April 2019. All randomized controlled trials (RCTs) will be included in this network meta-analysis (NMA) and their risk of bias will be assessed using Cochrane handbook tool by 2 independent authors. The efficacy outcomes including: Back and Leg Visual Analog Scale (VAS) score, MacNab criteria, the Oswestry Disability Index (ODI), and Japanese Orthopedic Association (JOA) score. The safety outcomes including: incidence of complications (dura tear, incomplete decompression, reoperation, etc.). A network meta-analysis will be performed using R x64 3.5.1 software and pairwise meta-analysis will be conducted using Stata 12.0 software. Grading of recommendations assessment, development, and evaluation (GRADE) will be used to assess evidence quality. Results: The results of NMA will be submitted to a peer-reviewed journal. Conclusion: The NMA will provide a comprehensive evidence summary on treatments for patients with LSS.