文献类型：期刊文献

英文题名：Myocardial fibrosis and glycolysis: a bibliometric study and visualization analysis (2000-2024)

作者：Chen, Qilin[1,2,3,4];Ye, Xiaoxia[2,3,4];Shu, Chang[2,3,4];Ren, Chunzhen[2,3,4];Wang, Xuehan[3,4,5];Jiang, Hugang[2,3,4];Zhi, Xiaodong[2,3,4];Li, Linchan[2,3,4];Li, Qianrong[2,3,4];Liu, Kai[4,6];Zhao, Xinke[2,3,4];Li, Yingdong[2,3,4]

第一作者：Chen, Qilin

通信作者：Li, YD[1];Li, YD[2];Li, YD[3]

机构：[1]KweiChow Moutai Hosp, Renhuai, Peoples R China;[2]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[3]Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou, Peoples R China;[4]Natl Adm Tradit Chinese Med, Key Specialized Cardiovasc Lab, Key Clin Specialty Natl Hlth Commiss Peoples Repub, Lanzhou, Peoples R China;[5]Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[6]Gansu Med Coll, Pingliang, Peoples R China

第一机构：KweiChow Moutai Hosp, Renhuai, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou, Peoples R China;[3]corresponding author), Natl Adm Tradit Chinese Med, Key Specialized Cardiovasc Lab, Key Clin Specialty Natl Hlth Commiss Peoples Repub, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：24

期号：1

外文期刊名：JOURNAL OF TRANSLATIONAL MEDICINE

收录：;Scopus(收录号：2-s2.0-105036997706);WOS:【SCI-EXPANDED(收录号:WOS:001748726700001)】；

基金：This work was supported by the 2021 Gansu Jiaoyu Jiebang Guashuai Project (No. 2021 jyjbgs-03), Gansu Province Traditional Chinese Medicine Prevention and Treatment of Major Diseases Special Project (No. GZKZD-2018-02), Gansu Province Major Science and Technology Special Project (No.20ZD7FA002), 2022 Gansu Province Longyuan Youth Innovation and Entrepreneurship Talent Project, 2022 Gansu Province natural sciences fund (22JR11RA128) and National Natural Science Foundation of China (NO. 82260869), National Administration of Traditional Chinese Medicine Youth Qihuang Scholars Support Project. National Natural Science Foundation of China (NO. 82360926), 2024 Gansu Province Outstanding Doctoral Project (24JRRA569).

语种：英文

外文关键词：Bibliometrics; CiteSpace; VOSviewer; Visual Analysis; Myocardial Fibrosis; Glycolysis

摘要：Background Myocardial fibrosis represents a terminal pathological outcome in numerous cardiovascular diseases and is mechanistically linked to glycolytic dysregulation. However, systematic reviews integrating multidimensional evidence remain scarce. Objective This study aims to conduct a visual analysis of myocardial fibrosis and glycolysis research using CiteSpace and VOSviewer, quantifying research trends and key contributors. Methods Literature on "myocardial fibrosis" and "glycolysis" published between January 1, 2000, and December 31, 2024, was retrieved from the Web of Science, PubMed, and Scopus databases. After deduplication, 408 articles were included for analysis. CiteSpace and VOSviewer were employed to analyze data regarding countries, institutions, authors, and keywords. Results A total of 408 studies were included. Annual publications on myocardial fibrosis and glycolysis exhibited a fluctuating upward trend, increasing from 1 (2000) to 51 (2024). These publications were divided into three phases: Initial Exploration (2000-2003, 1 article per year), Slow Fluctuation (2004-2009, 3-5 articles per year), and Rapid Development (2010-2024). During the Rapid Development phase, publications surged from 25 in 2019 to 44 in 2020, peaked in 2021-2022 (45 and 48 articles, respectively), and rebounded to 51 in 2024. Key contributors: The U.S. (177 studies, 32% of global output) and China (115 studies, 20%) were the leading contributors, collectively accounting for 52% of total publications; top institutions were Univ. of Alberta (15 Myocardial fibrosis representstudies) and Univ. of Utah (14 studies); core authors included Archer, S.L. (10 studies) and Chen, J.-X. (8 studies), with Lopaschuk, G.D. topping co-citations (117). High-frequency keywords: "heart failure" (107), "expression" (81), "metabolism" (60), "glycolysis" (44); high-centrality ones: "cardiac hypertrophy" (0.25), "fatty acid oxidation" (0.21). Emerging frontiers: "extracellular matrix" (burst intensity = 3.01, 2021-2024), "pulmonary hypertension" (3.61, 2022-2024). Clustering analysis identified 10 clusters (Silhouette Value = 0.7628, Modularity Q = 0.5292), including #0 pulmonary arterial hypertension (2014) and #10 mitochondrial dysfunction (2019). Conclusion Our bibliometric analysis reveals three pivotal trends: (1) The U.S. (32%) and China (20%) lead international collaborative networks; (2) Glycolytic reprogramming, oxidative stress, and metabolic interventions are prevalent research focuses; (3) Mitochondrial dysfunction and extracellular matrix remodeling are emerging frontiers. These findings clarify the glycolysis-fibrosis axis and provide a framework for targeted anti-fibrotic therapies.