文献类型：期刊文献

英文题名：Linear PVA-DTPA-Gd conjugate for magnetic resonance imaging

作者：Xu, Weibing[1];Lin, Zhiyan[2];Li, Guichen[3];Long, Haitao[1];Du, Mingyuan[1];Fu, Guorui[1];Pu, Lumei[1]

第一作者：Xu, Weibing

通信作者：Xu, WB[1];Pu, LM[1];Lin, ZY[2]

机构：[1]Gansu Agr Univ, Coll Sci, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Agr Univ, Gansu Prov Key Lab Aridland Crop Sci, Lanzhou 730070, Gansu, Peoples R China

第一机构：Gansu Agr Univ, Coll Sci, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Agr Univ, Coll Sci, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Clin Med Coll, Lanzhou 730000, Gansu, Peoples R China.|[10735c1ddf597548aedb5]甘肃中医药大学临床医学院;[10735]甘肃中医药大学;

年份：2019

卷号：9

期号：63

起止页码：37052

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20194707723898);Scopus(收录号：2-s2.0-85075244606);WOS:【SCI-EXPANDED(收录号:WOS:000498519000056)】；

基金：The authors gratefully acknowledge the support of scientific research start-up funds for openly-recruited doctors (No: 2017RCZX-42) and special funds for discipline construction of Gansu Agricultural University (No: GAU-XKJS-2018-131). All animal procedures were performed in accordance with the Guidelines for Care and Use of Laboratory Animals of Gansu Agricultural University and approved by the Animal Ethics Committee of Gansu Agricultural University.

语种：英文

外文关键词：Biocompatibility

摘要：In this study, we report the preparation and characterization of the PVA-DTPA-Gd conjugate as a potential MRI contrast agent (CA). The r(1) value and the r(2)/r(1) ratio were about 5.6 mM(-1) s(-1) and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA.