文献类型：期刊文献

英文题名：Copper in cancer: from limiting nutrient to therapeutic target

作者：Tang, Xiaolong[1,2];Yan, Zaihua[1,2];Miao, Yandong[3];Ha, Wuhua[1];Li, Zheng[4,5];Yang, Lixia[6];Mi, Denghai[1,6]

第一作者：Tang, Xiaolong

通信作者：Mi, DH[1];Yang, LX[2];Mi, DH[2]

机构：[1]Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]North Sichuan Med Coll, Affiliated Hosp, Dept Gastrointestinal Surg 2, Nanchong, Sichuan, Peoples R China;[3]Binzhou Med Univ, Yantai Affiliated Hosp, Clin Med Coll 2, Dept Oncol, Yantai, Shandong, Peoples R China;[4]Sichuan Univ, West China Hosp, Div Thorac Tumor Multimodal Treatment, Chengdu, Sichuan, Peoples R China;[5]Sichuan Univ, West China Hosp, Canc Ctr, Dept Radiat Oncol, Chengdu, Sichuan, Peoples R China;[6]Gansu Acad Tradit Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Acad Tradit Chinese Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：13

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85164602863);WOS:【SCI-EXPANDED(收录号:WOS:001023608400001)】；

基金：This work was supported by the Special Plan for Condition Construction of [Gansu Provincial Scientific Research Institutes] (Grants No. 20JR10RA432) and Research Development Fund project of North Sichuan Medical College of [Department of Science and Technology, North Sichuan Medical College] (Grants No. CBY22-QNA12).

语种：英文

外文关键词：copper metabolism; anticancer; Cu chelators; Cu ionophores; potential drugs

摘要：As an essential nutrient, copper's redox properties are both beneficial and toxic to cells. Therefore, leveraging the characteristics of copper-dependent diseases or using copper toxicity to treat copper-sensitive diseases may offer new strategies for specific disease treatments. In particular, copper concentration is typically higher in cancer cells, making copper a critical limiting nutrient for cancer cell growth and proliferation. Hence, intervening in copper metabolism specific to cancer cells may become a potential tumor treatment strategy, directly impacting tumor growth and metastasis. In this review, we discuss the metabolism of copper in the body and summarize research progress on the role of copper in promoting tumor cell growth or inducing programmed cell death in tumor cells. Additionally, we elucidate the role of copper-related drugs in cancer treatment, intending to provide new perspectives for cancer treatment.