文献类型：期刊文献

中文题名：中药复方调控细胞焦亡防治溃疡性结肠炎的研究进展

英文题名：Regulation of pyroptosis by traditional Chinese medicine compound formulas for prevention and treatment of ulcerative colitis:a review

作者：温瑞瑞[1];李思琦[1];李萌新[1];李淑霞[2]

第一作者：温瑞瑞

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃中医药大学第二附属医院肛肠科,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2025

卷号：50

期号：23

起止页码：6598

中文期刊名：中国中药杂志

外文期刊名：China Journal of Chinese Materia Medica

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金地区科学基金项目(81560746);甘肃省省级中医特色优势专科(肛肠科)项目(00211500101);兰州市科技计划项目(2023-ZD-219)。

语种：中文

中文关键词：溃疡性结肠炎;细胞焦亡;中药复方;研究进展

外文关键词：ulcerative colitis;pyroptosis;traditional Chinese medicine compound;research progress

摘要：溃疡性结肠炎(UC)是一种治愈难、复发率高的肠道炎症疾病,其特征是结肠黏膜炎症和损伤,对患者的生活质量造成严重影响。目前,UC的治疗以皮质类固醇、氨基水杨酸盐、生物制剂和免疫调节剂等药物治疗为主,但存在耐药性强和药物不良反应大等局限性。细胞焦亡作为一种高度炎症的程序性细胞死亡形式,可通过调控其下游多种靶点,从多种途径调节UC的发生发展,因此,细胞焦亡为UC的治疗提供新的研究方向。多项研究表明,细胞焦亡可以通过调控炎症因子释放、炎症小体及肠道功能稳态、炎症小体及肠道微生物群,干预UC的发生发展。中医药因其不良反应少、个性化诊疗以及增效减毒的独特优势而愈加受到重视。除了传统的中药复方,更多的中药单体及提取物因具有更精准的作用靶点扮演关键角色。研究发现,清热祛湿、活血通络、补益气血、寒热错杂等类别的中药复方可通过靶向细胞焦亡,维持肠道稳态、调节肠道微生物群、抑制肠道氧化应激等途径有效减轻炎症,从而干预UC发展,为其精准治疗提供了新的可能。基于此,该文将从细胞焦亡概述、细胞焦亡与UC的关系及中医药调控机制等3个方面进行阐述,对近年来该领域的研究成果进行归纳与总结,以期为今后UC的临床治疗及药物研发提供理论依据。
Ulcerative colitis(UC)is a refractory inflammatory bowel disease with a high recurrence rate,characterized by inflammation and damage to the colonic mucosa,which severely impacts patients′quality of life.Current treatments for UC primarily rely on pharmacological interventions,including corticosteroids,aminosalicylates,biologics,and immunomodulators,but these approaches are limited by strong drug resistance and significant adverse effects.Pyroptosis,a highly inflammatory form of programmed cell death,can regulate the occurrence and progression of UC through multiple pathways by modulating diverse downstream targets,thereby providing a novel direction for UC therapy.Multiple studies have shown that pyroptosis can intervene in UC development by regulating the release of inflammatory cytokines,inflammasome activity,intestinal homeostasis,and the gut microbiota.Traditional Chinese medicine(TCM)has gained increasing attention due to its minimal adverse effects,personalized therapeutic strategies,and unique advantages in enhancing efficacy while reducing toxicity.Beyond traditional compound formulas,individual TCM herbs and extracts play a pivotal role owing to their more precise target specificity.Research indicates that TCM compound formulas classified as heat-clearing and dampness-eliminating,blood-activating and collaterals-unblocking,Qi-and blood-tonifying,or addressing cold-heat complex patterns can effectively alleviate inflammation by targeting pyroptosis.This is achieved through mechanisms such as maintaining intestinal homeostasis,regulating the gut microbiota,and inhibiting intestinal oxidative stress,thereby intervening in UC progression and offering new possibilities for precision therapy.Based on this,this paper discusses three aspects:an overview of pyroptosis,the relationship between pyroptosis and UC,and the regulatory mechanisms of TCM.It summarizes recent research findings in this field,aiming to provide a theoretical basis for future clinical treatment and drug development for UC.