文献类型：期刊文献

中文题名：镉与儿童孤独症相关性的Meta分析

英文题名：The relationship between cadmium and childhood autism:a meta-analysis

作者：王佳斌[1,2];魏莉莉[3];王蒙[1];刘璐[4];王燕侠[2];王称[2];虎亚光[2];黄佩瑶[1];邱文文[4];刘旭栋[2];李甫云[1];仇杰[1,2];杨克虎[3]

第一作者：王佳斌

机构：[1]兰州大学公共卫生学院,兰州730000;[2]甘肃省妇幼保健院,兰州730050;[3]兰州大学循证医学中心,兰州730000;[4]甘肃中医药大学,兰州730000

第一机构：兰州大学公共卫生学院,兰州730000

年份：2020

卷号：20

期号：6

起止页码：702

中文期刊名：中国循证医学杂志

外文期刊名：Chinese Journal of Evidence-based Medicine

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

语种：中文

中文关键词：孤独症;儿童;镉;Meta分析;系统评价;病例-对照研究

外文关键词：Autistic disorder;Children;Cadmium;Meta-analysis;Systematic review;Case-control study

摘要：目的系统评价镉与儿童孤独症的相关性。方法计算机检索PubMed、EMbase、Web of Science、The Cochrane Library、CNKI、VIP、WanFang Data和CBM数据库,搜集关于镉与儿童孤独症相关性的病例-对照研究,检索时限均为建库至2019年7月。由2名研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入8个病例-对照研究。Meta分析结果显示,无论标本来源为全血、尿液还是头发,儿童孤独症病例组与对照组镉浓度的差异均无统计学意义[MD全血=0.17,95%CI(-0.06,0.39),P=0.15;MD尿液=-0.43,95%CI(-1.44,0.58),P=0.4;MD头发=-0.08,95%CI(-0.52,0.36),P=0.72]。结论当前证据显示,镉浓度与儿童孤独症发生并无相关性。受纳入研究数量和质量限制,上述结论尚需更多高质量研究予以验证。
Objective To systematically review the relationship between cadmium(Cd)and childhood autism.Methods PubMed,EMbase,Web of Science,The Cochrane Library,CNKI,VIP,WanFang Data and CBM were electronically searched to collect case-control studies on the relationship between Cd and childhood autism from inception to July 2019.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies.Then,meta-analysis was performed by using RevMan 5.3 software.Results A total of 8 case-control studies were included.The results of meta-analysis showed that whether the specimen was from whole blood,urine or hair,there were no correlations between Cd and childhood autism(MDblood=0.17,95%CI-0.06 to 0.39,P=0.15;MDurine=-0.43,95%CI-1.44 to 0.58,P=0.4;MDhair=-0.08,95%CI-0.52 to 0.36,P=0.72).Conclusions Current evidence shows that Cd concentration is not correlated with autism in children.Due to limited quality and quantity of the included studies,more high quality studies are required to verify above conclusions.