文献类型：期刊文献

中文题名：西黄丸抗肿瘤作用机制及其联合抗肿瘤研究进展

英文题名：Anti-tumor Mechanism of Xihuangwan and Research Progress on Its Combined Use in Anti-tumor Treatment

作者：夏顺利[1];王雪[1];翟勇聪[1];刘景楠[1];韩涛[1,2]

第一作者：夏顺利

机构：[1]甘肃中医药大学药学院,兰州730000;[2]甘肃省中药药理与毒理学重点实验室,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2021

卷号：27

期号：6

起止页码：217

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金地区基金项目(81560722)。

语种：中文

中文关键词：西黄丸;抗肿瘤;作用机制;联合抗肿瘤;研究现状

外文关键词：Xihuangwan;anti-tumor;mechanism of action;combined use for anti-tumor;research status

摘要：西黄丸由牛黄、乳香、没药、麝香4味中药组方而成。现代药理学研究表明,西黄丸具有抗炎、抗菌、抗肿瘤、抗乳腺增生以及增强机体免疫功能等作用。恶性肿瘤是由环境因素和遗传因素共同作用引起的一种发病机制比较复杂的疾病,严重危害着人类健康和生命安全,也是我国居民死亡的主要原因之一。目前临床上用于抗肿瘤的化疗药物除了具有毒副作用,影响临床疗效和患者预后外,长期使用还会使肿瘤产生耐药性。西黄丸作为传统经典抗癌名方,随着中医药文化的兴起,被越来越多的应用于肿瘤的研究中,对肝癌、胃癌、肺癌、乳腺癌、结肠癌等多种恶性肿瘤具有显著抑制作用。临床上西黄丸多被作为辅助药联合化疗药抗肿瘤使用,降低化疗药的毒副作用和患者的不良反应,提高患者对化疗的耐受性,还可延长或降低术后肿瘤的复发,增强机体的免疫功能,逆转肿瘤细胞的耐受性。在西黄丸抗肿瘤研究的基础上,对其诱导细胞凋亡、调节氨基酸代谢、逆转耐药性、干扰细胞周期、抗肿瘤转移侵袭、调节免疫功能、改善肿瘤微环境、调控信号通路等8个方面的作用机制及其临床上联合化疗药抗肿瘤进行归纳总结,分析西黄丸抗肿瘤的研究现状,并且针对其现状提出不足之处和尚待解决的问题,为西黄丸的进一步研究和临床应用提供理论依据。
Xihuangwan is composed of four Chinese medicines:Bovis Calculus,Olibanum,Myrrha,and Moschus.Modern pharmacology studies have shown that Xihuangwan has anti-inflammatory,antibacterial,anti-tumor,anti-mammary gland hyperplasia effect,and can enhance the body’s immune function.Cancer seriously endangers public health and safety-of-life,and is a major cause of mortality of Chinese citizens.It is a disease with intricate etiopathogenesis caused by the joint action of circumstances and hereditary factors.At present,anti-tumor chemotherapy drugs in clinical application not only have toxic and side effect,but also affect clinical efficacy and prognosis of patients.Long-term use will also lead to drug resistance of tumors.As a traditional classic anti-cancer prescription,Xihuangwan has been used more and more in tumor research with the rise of Chinese medicine culture.It is provided with remarkable inhibitory effect on liver cancer,gastric cancer,carcinoma of the lungs,mammary gland,colorectal carcinoma and other malignant tumors.In clinical practice,Xihuangwan,mostly used as adjuvant drugs in combined use with chemotherapy drugs for anti-tumor effect,can reduce the side effect of chemotherapy drugs and the untoward reaction of sufferers,improve the survivability of patients to chemotherapy,reduce or delay postoperative tumor recurrence,enhance the body’s immune function,and reverse the tolerance of tumor cells.Based on the anti-tumor research of Xihuangwan,we summarized its mechanisms in inducing cell apoptosis,regulating amino acid metabolism,reversing drug resistance,interfering with cell cycle,resisting tumor metastasis and invasion,regulating immune function,improving tumor microenvironment,and regulating signal pathways,as well as its clinical combination with chemotherapeutic anti-tumor drugs,analyzed the current anti-tumor research status of Xihuangwan’s research,and put forward the shortcomings and unresolved problems in order to provide theoretical basis for further research and clinical application of Xihuangwan.