文献类型：期刊文献

中文题名：慢性阻塞性肺疾病中黏蛋白5AC生成增多的机制及中医药干预研究进展

英文题名：Mechanism and Research Progress of Chinese Medicine Intervention ofIncreased Production of MUC5AC in Chronic Obstructive Pulmonary Disease

作者：侯红豆[1];张利英[1];李洋洋[1];牛帆[1];李静[1];韵成才[1];雍文兴[2]

第一作者：侯红豆

机构：[1]甘肃中医药大学,甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2024

卷号：52

期号：2

起止页码：108

中文期刊名：中医药学报

外文期刊名：Acta Chinese Medicine and Pharmacology

收录：CSTPCD

基金：国家自然科学基金项目(82160868);甘肃省自然科学基金(20JR10RA343)。

语种：中文

中文关键词：慢性阻塞性肺疾病;黏液;分子机制;黏蛋白5AC;中药复方;中药化合物

外文关键词：Chronic obstructive pulmonary disease;Mucus;Molecular mechanism;MUC5AC;Traditional Chinese medicine formulas;Traditional Chinese Medicine compounds

摘要：慢性阻塞性肺疾病(COPD)是一种常见的慢性呼吸系统疾病,主要表现为长期气流受限和呼吸困难。气道黏蛋白过度生成是COPD的主要危险因素,与肺功能降低有关。黏蛋白5AC(MUC5AC)是气道上皮的主要黏蛋白,其异常表达会阻塞气道,降低肺功能,促进COPD的发展。MUC5AC的异常产生和分泌涉及多种途径,NF-κB、PI3K/Akt、EGFR、IL-13/STAT6/SPDEF、p38MAPK通路均与MUC5AC的生成密切相关。中药复方和中药有效化合物具有抗炎、调节黏液作用,对黏蛋白的异常表达具有调节作用。本文就上述信号通路与MUC5AC的关系、抑制MUC5AC产生的中药复方和中药有效化合物做一综述,以期为治疗COPD提供一些思路。
Chronic obstructive pulmonary disease(COPD)is a common chronic respiratory disease characterized by long-term airflow restriction and difficulty in breathing.Airway mucin overproduction is a major risk factor for COPD and is associated with reduced lung function.Mucin 5AC(MUC5AC)is the main mucin in the airway epithelium.Abnormal mucin expression obstructs the airway,reduces lung function and promotes the occurrence and development of COPD.Abnormal production and secretion of MUC5AC are involved in various pathways,NF-κB,PI3K/AKT,EGFR,IL-13/STAT6/SPDEF and p38MAPK pathways are closely associated with the production of MUC5AC.Traditional Chinese medicine formulas and effective compounds have anti-inflammatory and mucus regulating effects,as well as regulatory effects on abnormal expression of mucin.This article reviews the relationship between the above signaling pathways and MUC5AC,the natural inhibitors that inhibit the production of MUC5AC,and effective compounds of Chinese medicine,in order to provide some ideas for the treatment of COPD.