文献类型：期刊文献

英文题名：Risk and pattern analysis of distant metastases in colon cancer: protocol for a systematic review and meta-analysis

作者：Hu, Yonghua[1,2,3];Wei, Qinglin[4];Yu, Yang[1,5];Li, Haiyuan[1,5];Chen, Hao[1]

第一作者：呼永华;Hu, Yonghua

通信作者：Chen, H[1]

机构：[1]Lanzhou Univ, Clin Med Coll 2, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Dept Oncol, Affiliated Hosp, Lanzhou, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Acupuncture Ctr, Affiliated Hosp, Lanzhou, Peoples R China;[5]Lanzhou Univ Second Hosp, Dept Tumor Surg, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Clin Med Coll 2, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ Second Hosp, Dept Tumor Surg, Lanzhou 730000, Peoples R China.

年份：2024

卷号：28

期号：4

起止页码：114

外文期刊名：INTERNATIONAL JOURNAL OF SURGERY PROTOCOLS

收录：WOS:【ESCI(收录号:WOS:001386170400004)】；

基金：This work was supported by the Gansu Provincial Health and Health Industry Research Plan Management Project (Grant No. GSWSKY2020-60) , the Gansu Provincial Science and Technology Department Key R&D Program-Social Development Project (Grant No. 23YFFA0067) , Gansu University of Chinese Medicine Open Subjects of Gansu Traditional Chinese Medicine Research Center (Grant No. zyzx-2023-15) , the Gansu Provincial Higher Education Innovation Fund Project (Grant No. 2022A-071) , the Lanzhou City Science and Technology Development Plan Project (Grant No. 2021-1-99) , the Research Project on COVID-19 Prevention and Control Technologies (Grant No. 2020-XG-27) , the Scientiffc Research and Innovation Fund Project of Gansu University of Chinese Medicine (Grant No. 2019KC2D-1) , the General Project of In-hospital Research in 2022 at Afffliated Hospital of Gansu University of Chinese Medicine (Grant No. gzfy-2022-07) , the Open Fund Project of the Provincial Key Laboratory for Molecular Medicine and TCM Prevention and Treatment of Major Diseases in Higher Education Institutions in Gansu Province (Grant No. FZYX15-16-8) , the Research Project of Higher Education Institutions in Gansu Province (Grant No. 2016A-045) , Gansu Provincial Natural Science Foundation (Grant No. 17JR5A169) , Technical Research and Development Special Plan of Gansu Provincial Department of Science and Technology (Grant No. 1105TCYA019) . These funders have no involvement in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.

语种：英文

外文关键词：colon cancer; meta-analysis; metastasis; proportion; systematic review

摘要：Background: Understanding the metastatic risks and patterns of colon cancer is crucial for patient evaluation and decision- making. However, high-quality evidence on colon cancer metastases is lacking. This study aims to conduct a systematic review and meta-analysis to determine the risk of site-specific metastasis and provide a complete profiling of distant metastasis in colon cancer. Methods: This review will include studies reporting the proportion of different-site metastases among colon cancer patients. Clinical trials, follow-up studies, and cross-sectional surveys with English publications are eligible for inclusion. We will search Medline, Embase, Web of Science, and the Cochrane Library from inception to June 2023. Two reviewers will independently screen the title/abstract and full texts of identified records according to the eligibility criteria. Data from eligible studies will be extracted and used for meta-analysis. Meta-analyses will be conducted to estimate the overall proportion of site-specific metastasis. During meta-analyses, two proportions will be analyzed, i.e., the incidence of metastasis and component proportion. We will select the appropriate tools to assess the risk of biases based on the study design of included studies. Results: This study is still in preparation for launch. Once all analyses are complete, the results will be submitted for publication in a peer-reviewed journal. Conclusion: This review will provide a clear and systematic metastatic pattern of colon cancer and evidence-based recommendations for the management of distant metastasis.