文献类型：期刊文献

中文题名：加味逍遥散治疗肝郁脾虚型2型糖尿病伴情绪障碍患者的临床观察

英文题名：Clinical Observation of Jiawei Xiaoyaosan in Treating Liver Depression and Spleen Deficiency Type 2 Diabetes with Emotional Disorder

作者：李芳芳[1];康学东[2]

第一作者：李芳芳

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院,兰州730020

第一机构：甘肃中医药大学

年份：2019

卷号：25

期号：2

起止页码：134

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：甘肃中医药大学研究生创新基金项目(CX2018-12)

语种：中文

中文关键词：加味逍遥散;肝郁脾虚;2型糖尿病;情绪障碍

外文关键词：Jiawei Xiaoyaosan;liver depression and spleen deficiency;type 2 diabetes;dysthymic disorder

摘要：目的:观察加味逍遥散治疗肝郁脾虚型2型糖尿病伴焦虑、抑郁情绪障碍患者的临床疗效。方法:选取符合纳入标准的肝郁脾虚型2型糖尿病伴焦虑、抑郁情绪障碍患者76例,随机分为对照组和治疗组,各38例。对照组给予基础药物二甲双胍缓释片联合黛力新治疗,治疗组在对照组的基础上联合加味逍遥散治疗。观察用药前后患者空腹血糖(fasting plasma glucose,FPG),餐后2 h血糖(2 hours postprandial blood glucose,2 h PG),糖化血红蛋白(haemoglobin A1c,HbA1c),空腹血清胰岛素(FINS)水平及服糖后30 min血清胰岛素(30 min INS)水平,汉密尔顿抑郁量表评分(HAMD),汉密尔顿焦虑量表评分(HAMA)等指标的变化。结果:与本组治疗前比较,两组患者FPG,2 h PG,HbA1c水平均明显降低(P <0. 05),FINS水平显著下降(P <0. 01),服糖后30 min INS水平明显升高(P <0. 05),HAMD评分,HAMA评分明显降低(P <0. 05);治疗后与对照组比较,治疗组患者FBG,2 h PG,HbA1c水平均显著降低(P <0. 01),治疗组FINS水平明显降低(P <0. 05),服糖后30 min INS水平明显升高(P <0. 05),治疗组HAMD,HAMA评分显著降低(P <0. 01),两组不良反应无明显差异。结论:加味逍遥散联合基础用药可以明显减轻肝郁脾虚型2型糖尿病伴情绪障碍患者的抑郁、焦虑程度,降低患者血糖、糖化血红蛋白,降低空腹胰岛素,升高服糖30 min INS水平,其作用可能与改善此类患者焦虑、抑郁等不良情绪有关。
Objective: To observe the clinical efficacy of Jiawei Xiaoyaosan for patients with anxiety and depression in type 2 diabetes with liver depression and spleen deficiency. Method: The 76 eligible patients with anxiety and depression in type 2 diabetes with liver depression and spleen deficiency were randomly divided into two groups: control group( 38 cases) and treatment group( 38 cases). In control group,the basic medicines metformin sustained-release tablets combined with deanxit were given;based on the treatment in control group,the patients in treatment additionally received Jiawei Xiaoyaosan. The changes of fasting plasma glucose( FPG),2 hours postprandial blood glucose( 2 hPG),haemoglobin A1c( HbA1c),fasting insulin( FINS) and serum insulin levels 30 minutes after glucose intake( 30 min INS),Hamilton depression scale( HAMD),Hamilton anxiety scale( HAMA) and so on were observed and compared. Result: As compared with those before treatment,the levels of FPG,2 hPG and HbA1c were decreased significantly( P < 0. 05),fasting serum insulin levels were significantly decreased( P < 0. 01),30 min INS levels were increased( P < 0. 05);HAMD and HAMA scores were significantly decreased( P < 0. 05). After treatment,the levels of FPG,2 hPG and HbA1c in the treatment group were significantly lower than those in control group( P < 0. 01),and the FINS level in treatment group was lower( P < 0. 05) while 30 min INS level was higher than those in control group( P < 0. 05);in addition,the HAMD and HAMA scores in the treatment group were significantly lower than those in control group( P < 0. 01),but there was no significant difference in adverse reactions between two groups. Conclusion: Jiawei Xiaoyaosan combined with basic medication can significantly reduce depression and anxiety in patients with type 2 diabetes mellitus of liver depression and spleen deficiency,reduce blood glucose,glycosylated hemoglobin,decrease fasting insulin and increase 30 min INS level. The effect may be related to the improvement of anxiety,depression and other adverse emotions in these patients.