文献类型：期刊文献

中文题名：中药诱导骨髓间充质干细胞的定向分化:研究与进展

英文题名：Directional differentiation of bone marrow mesenchymal stem cell induced by traditional Chinese Medicine

作者：李宁[1];李应福[1];谢兴文[2];宋敏[1];徐世红[2];李鼎鹏[2]

第一作者：李宁

机构：[1]甘肃中医药大学,甘肃省兰州市730000;[2]甘肃省中医院,甘肃省兰州市730050

第一机构：甘肃中医药大学

年份：2016

卷号：20

期号：1

起止页码：135

中文期刊名：中国组织工程研究

外文期刊名：Chinese Journal of Tissue Engineering Research

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；

基金：国家自然科学基金资助项目(81460735);甘肃省自然科学基金项目(1010RJZA217)~~

语种：中文

中文关键词：骨髓;间质干细胞;中草药;骨疾病;组织工程;干细胞;培养;中药;骨髓间充质干细胞;诱导分化;研究进展;骨伤疾病;国家自然科学基金

外文关键词：Bone Marrow; Mesenchymal Stem Cells; Drugs; Chinese Herbal; Bone Diseases; Tissue Engineering

摘要：背景:近年来,对传统单味中药或提取物、复方中药及含药血清调控骨髓间充质干细胞定向分化为肌成纤维细胞、软骨细胞、成骨细胞、心肌细胞、神经细胞等研究的不断深入,使中药或其提取物对骨髓间充质干细胞增殖、调控定向分化和移植等方面成为组织工程研究领域的一大亮点。目的:综述中药或其提取物诱导骨髓间充质干细胞定向分化的最新研究进展。方法:分别以"中药,定向分化,骨髓间充质干细胞","Chinese herb,directional differentiation,mesenchymal stem cells"为检索词,由第一作者检索2010年1月至2016年1月中国期刊全文数据库、Pub Med数据库及万方数据库相关文章。排除缺乏原创性及重复性研究的文献,计算机初检到99篇文献,最终保留43篇进行归纳总结。结果与结论:骨髓间充质干细胞作为骨分化系统中最强的种子细胞,具有广泛的定向分化潜能,与传统中草药结合在临床治疗众多难治性疾病中凸显重要价值,尤其对于治疗骨代谢疾病、骨缺损、骨折不愈合及迟缓愈合等疾病更加充分发挥其临床应用价值,这既有利于进一步深层次,多角度研究中药的作用及发生机制,也使骨髓间充质干细胞向更宽、更广领域参与临床各类难治性疾病的治疗。
BACKGROUND： In recent years, in-depth studies that single Chinese herbs or extracts, compound traditional Chinese medicine and medicated serum are used to regulate the directional differentiation of bone marrow mesenchymal stem cells into myofibroblasts, chondrocytes, osteoblasts, myocardial cells and nerve cells, which have become a highlight in the tissue engineering research. OBJECTIVE： To review the latest progress in the directional differentiation of bone marrow mesenchymal stem cells induced by Chinese herbs or their extracts. METHODS： The first author searched the CNKI, Wanfang and Pub Med databases using the keywords of ＂Chinese herb, directional differentiation, mesenchymal stem cells＂ in Chinese and English, respectively, to retrieve relevant articles published from January 2010 to January 2016. Repetitive articles or those with no originality were eliminated. Totally 99 articles were searched initially, and then 43 articles were included in result analysis. RESULTS AND CONCLUSION： As the strongest seed cells in the bone differentiation system, bone marrow mesenchymal stem cells have a wide range of directional differentiation potential, and highlight the important value in combination with Chinese herbs for clinical treatment of various refractory diseases, especially for treatment of metabolic bone diseases, bone defects, nonunion and delayed union, which is not only conducive to in-depth, multi-angle studies on effects and mechanisms of Chinese herbs, but also to clinical treatment of various refractory diseases using bone marrow mesenchymal stem cells.