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Effect of Thyroid-Stimulating Hormone Suppression Therapy on Cardiac Structure and Function in Patients With Differentiated Thyroid Cancer After Thyroidectomy: A Systematic Review and Meta-Analysis  ( SCI-EXPANDED收录)   被引量:2

文献类型:期刊文献

英文题名:Effect of Thyroid-Stimulating Hormone Suppression Therapy on Cardiac Structure and Function in Patients With Differentiated Thyroid Cancer After Thyroidectomy: A Systematic Review and Meta-Analysis

作者:Zhang, Hongling[1,2];Yang, Yanlong[1,2];Gao, Cuixia[3];Tian, Limin[1,2,4]

第一作者:张惠玲;张虎林;Zhang, Hongling

通信作者:Tian, LM[1]

机构:[1]Gansu Univ Chinese Med, Clin Med Coll 1, Gansu Prov Hosp, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Hosp, Dept Ultrasonog, Lanzhou, Gansu, Peoples R China;[4]Gansu Prov Hosp, 204 Donggang West Rd,Weiyuan Rd St, Lanzhou, Gansu, Peoples R China

第一机构:甘肃中医药大学

通信机构:[1]corresponding author), Gansu Prov Hosp, 204 Donggang West Rd,Weiyuan Rd St, Lanzhou, Gansu, Peoples R China.

年份:2024

卷号:30

期号:2

起止页码:177

外文期刊名:ENDOCRINE PRACTICE

收录:;Scopus(收录号:2-s2.0-85182754920);WOS:【SCI-EXPANDED(收录号:WOS:001169499400001)】;

基金:We thank the authors for their cooperation and the support of the Foundation. This work was supported by the Natural Science Foundation of Gansu Province, China (20JR5RA153) and the National Natural Science Foundation of China (82060152).

语种:英文

外文关键词:differentiated thyroid cancer; TSH suppression therapy; cardiac effects; systematic review; meta-analysis

摘要:Objective: We aimed to evaluate the effects of thyroid-stimulating hormone (TSH) suppression therapy on cardiac structure and function in patients with differentiated thyroid cancer (DTC) following thyroidectomy. Methods: Two investigators independently searched the PubMed, Embase, Cochrane Library, and Web of Science databases for relevant studies published from inception to January 6, 2023, without any restrictions on language. Standard mean differences and 95% confidence intervals were calculated using fixed or random effects models. Thirteen clinical outcomes were analyzed, mainly evaluating cardiac morphology, systolic function, and diastolic function. Results: Thirteen studies were included in the quantitative analysis. Compared to healthy controls, left ventricular mass index, left ventricular posterior wall thickness, interventricular septal thickness, and isovolumic relaxation time values increased; the ratio of E-wave velocity to A-wave velocity and E-wave velocity values decreased. The left ventricular ejection fraction and cardiac output did not change in patients with DTC who underwent long-term TSH suppression therapy. Interventricular septal thickness values were significantly correlated with the duration of TSH suppression therapy. Conclusion: Long -term TSH suppression therapy leads to cardiac hypertrophy and impaired cardiac diastolic function in patients with DTC. These changes may be related to the duration of TSH suppression therapy. Large prospective studies with long follow-up periods are needed to validate these findings. (c) 2024 Published by Elsevier Inc. on behalf of the AACE.

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