文献类型：期刊文献

英文题名：Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis

作者：Yan, Chunlu[1];Zhang, Jinlong[2];An, Fangyu[3];Wang, Jiayu[3];Shi, Yao[4];Yuan, Lingqing[4];Lv, Donghui[3];Zhao, Yanzhen[3];Wang, Yongfeng[4]

第一作者：颜春鲁

通信作者：An, FY[1];Wang, YF[2]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：10

外文期刊名：FRONTIERS IN PUBLIC HEALTH

收录：;Scopus(收录号：2-s2.0-85134150309);WOS:【SSCI(收录号:WOS:000826485100001)，SCI-EXPANDED(收录号:WOS:000826485100001)】；

基金：This present study was funded by the grants from the National Natural Science Foundation of China (82060872), Natural Science Program in Gansu Province (21JR11RA138 and 20JR5RA616), the Project of Improving the Employment and Entrepreneurship Ability of College Students in Gansu Province (6-1), and the Project of Health Science and Technology Development in Lanzhou City (2021004).

语种：英文

外文关键词：ferroptosis; osteoporosis; bone formation; bone resorption; network regulation

摘要：Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. Other evidence supports that ferroptosis is participated osteoporotic bone remodeling, predominantly affecting the interaction between bone formation and bone resorption, explicitly bone resorption exceeded bone formation. Based on previous studies, this review will summarize the regulatory network mechanism of ferroptosis on bone remodeling and reveal the role of ferroptosis in osteoporosis (OP).