文献类型：期刊文献

中文题名：LncRNA SNHG6在消化系统肿瘤中作用的研究进展

英文题名：Research progress of LncRNA SNHG6 in digestive system tumors

作者：张亚妮[1,2];朱玲玲[1,2];何昱静[2];史婷婷[1,2];伍杨[1,2];高春[2];张久聪[2]

第一作者：张亚妮

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]中国人民解放军联勤保障部队第九四〇医院消化内科,甘肃兰州730050

第一机构：甘肃中医药大学临床医学院

年份：2024

卷号：44

期号：8

起止页码：878

中文期刊名：肿瘤

外文期刊名：Tumor

基金：中国高校优秀青年团队培育项目(31920220065);甘肃省卫生健康行业科研计划项目(GSWSKY2022-76);甘肃省青年科技基金(23JRRA1673);甘肃省卫生健康行业科研项目(GSWSKY2023-34)

语种：中文

中文关键词：消化系统肿瘤;lncRNA;SNHG6;化疗耐药;作用机制

外文关键词：Digestive system tumors;lncRNA;SNHG6;Chemotherapy resistance;Mechanism

摘要：消化系统肿瘤是一类恶性程度高、易转移且预后差的恶性肿瘤,因起病隐匿不易诊断,患者诊断时大多已达中晚期,因此治疗效果不佳。研究表明长链非编码RNA(long non-coding RNA,lncRNA)小核仁RNA宿主基因6(small nucleolar RNA host gene 6,SNHG6)在多种实体肿瘤中高表达,可参与肿瘤的增殖、侵袭和迁移等恶性生物学过程,并与化疗药物耐药性的产生密切相关。本文综述SNHG6在7种不同消化系统肿瘤中的生物学功能及临床意义,探讨其在肿瘤发生与发展中的作用机制,以期进一步寻找早期诊断及治疗的有效靶点,提高肿瘤患者的生存率。
Digestive system tumors are malignant tumors with high malignancy,easy metastasis,and poor prognosis,which are difficult to diagnose due to the insidious onset.Most of the patients have reached the middle and advanced stages at the time of diagnosis,so the effect of treatment is usually not good.Studies have shown that the long non-coding RNA(lncRNA)small nucleolar RNA host gene 6(SNHG6)is highly expressed in a variety of solid tumors,and can participate in malignant biological processes such as tumor proliferation,invasion and migration.SNHG6 is closely related to the emergence of chemotherapy drug resistance.This article reviews the biological function and clinical significance of SNHG6 in 6 different tumors of the digestive system,and discusses its mechanism of action in tumorigenesis and development,in the hope to search for effective early diagnosis and treatment targets and thereby improve the survival rate of cancer patients.