文献类型：期刊文献

英文题名：Angiogenesis in ossification of the posterior longitudinal ligament: progress from mechanism to targeted intervention

作者：Liu, Xiaoyu[1];Wang, Xiaomin[1];Hu, Kangyi[1];Wen, Haonan[2];Liu, Lu[1];Li, Haoxing[1];Che, Zhixin[1];Song, Ting[1];Lai, Jinquan[2];Song, Min[1];Song, Yongjia[1]

第一作者：刘芯宇;刘晓燕;刘熙钰;刘翔毅

通信作者：Song, M[1];Song, YJ[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Peoples R China;[2]Shenzhen Luohu Hosp Tradit Chinese Med, Shenzhen, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：14

外文期刊名：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

收录：;Scopus(收录号：2-s2.0-105033005688);WOS:【SCI-EXPANDED(收录号:WOS:001716885300001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the National Natural Science Foundation of China (82460943).

语种：英文

外文关键词：angiogenesis; angiogenesis-osteogenesis coupling; ossification of the posterior longitudinal ligament; signaling pathway; targeted intervention

摘要：Ossification of the posterior longitudinal ligament (OPLL) is a degenerative spinal disorder characterized by heterotopic ossification of ligamentous tissue. Its pathogenesis is multifactorial and complex, involving genetic susceptibility, chronic inflammation, mechanical stress, and metabolic dysregulation. In recent years, accumulating evidence has demonstrated that angiogenesis not only supplies essential nutrients and metabolic support to ossified ligament regions but also actively regulates the differentiation of mesenchymal stem cells toward osteogenic and chondrogenic lineages through specific molecular signaling pathways, thereby promoting ectopic bone formation. Focusing on angiogenesis as a central theme, this review systematically summarizes the mechanisms by which key molecules, including LOXL2, Sema3A, integrin alpha V beta 3, ANGPT2, IL-6, TGF-beta, the ACE D/D polymorphism, and YAP, mediate the coupling of angiogenesis and osteogenesis in OPLL. Furthermore, we propose angiogenesis-targeted strategies as a potential therapeutic avenue for OPLL, aiming to provide new theoretical insights and directions for both basic research and clinical intervention.