文献类型：期刊文献

英文题名：Nanoparticle-Mediated Cuproptosis and Photodynamic Synergistic Strategy: A Novel Horizon for Cancer Therapy

作者：Zhang, Junrui[1,2];Zhang, Anren[1];Guo, Yibing[1];Miao, Guoliang[1];Liang, Shengchang[1];Wang, Jie[3];Wang, Junhong[4]

第一作者：Zhang, Junrui

通信作者：Wang, J[1];Wang, JH[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Lanzhou, Peoples R China;[3]Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Peoples Hosp Baiyin 1, Dept Gen Surg, Affiliated Hosp 3, Baiyin, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Peoples Hosp Baiyin 1, Dept Gen Surg, Affiliated Hosp 3, Baiyin, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：14

期号：3

外文期刊名：CANCER MEDICINE

收录：;Scopus(收录号：2-s2.0-85216243480);WOS:【SCI-EXPANDED(收录号:WOS:001406950700001)】；

基金：This work was supported by the Second Group of Longyuan Young Talents in Gansu Province (Grant No. 2023-11). All figures in this article were created with . The rest of the reference illustrations have been authorized.

语种：英文

外文关键词：cancer; cuproptosis; PDT; therapy nanomaterials

摘要：BackgroundPhotodynamic therapy (PDT) is a noninvasive cancer treatment that works by using light to stimulate the production of excessive cytotoxic reactive oxygen species (ROS), which effectively eliminates tumor cells. However, the therapeutic effects of PDT are often limited by tumor hypoxia, which prevents effective tumor cell elimination. The oxygen (O2) consumption during PDT can further exacerbate hypoxia, leading to post-treatment adverse events.ObjectivesThis review aims to explore the potential of cuproptosis, a recently discovered copper-dependent form of programmed cell death, to enhance the anticancer effects of PDT. Cuproptosis is highly dependent on mitochondrial respiration, specifically the tricarboxylic acid (TCA) cycle, and can increase O2 and ROS levels or decrease glutathione (GSH) levels, thereby improving PDT outcomes.MethodsThe review discusses the latest research advancements in the field, detailing the mechanisms that regulate cuproptosis and PDT. It also explores how nanoparticle (NP)-based strategies can be used to exploit the synergistic potential between cuproptosis and PDT. The article examines the prospects of synergistic anticancer activity guided by nanodelivery systems, which could overcome the challenges associated with hypoxia in cancer treatment.ConclusionsThe combination of cuproptosis and PDT, facilitated by NP-based delivery systems, presents a promising approach to enhance the effectiveness of cancer therapy. The review concludes by discussing the challenges and future research directions for this combination therapy, highlighting the need for further investigation into the mechanisms and optimization of treatment strategies to improve outcomes in cancer treatment.