文献类型：期刊文献

英文题名：Radiotherapy versus no radiotherapy for rectal neuroendocrine carcinoma patients treated with surgery and chemotherapy: a population-based cohort study

作者：Liu, Xiaojun[1,2];Li, Jiaying[3];Benish, Farooq[4];Li, Shuping[1,2];Zhang, Weisheng[2,5]

第一作者：Liu, Xiaojun

通信作者：Zhang, WS[1];Zhang, WS[2]

机构：[1]Gansu Prov Hosp, Dept Radiotherapy, Lanzhou 730000, Peoples R China;[2]Lanzhou Univ, Clin Med Sch 3, Lanzhou 730030, Peoples R China;[3]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[4]Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China;[5]Gansu Prov Hosp, Dept Anorectal Surg, Lanzhou 730000, Gansu, Peoples R China

第一机构：Gansu Prov Hosp, Dept Radiotherapy, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Clin Med Sch 3, Lanzhou 730030, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Anorectal Surg, Lanzhou 730000, Gansu, Peoples R China.

年份：2025

卷号：16

期号：1

外文期刊名：DISCOVER ONCOLOGY

收录：;Scopus(收录号：2-s2.0-105013249586);WOS:【SCI-EXPANDED(收录号:WOS:001551654700005)】；

基金：The authors thank the Surveillance, Epidemiology, and End Results (SEER) database which provided data for our research.

语种：英文

外文关键词：Rectal malignancy; Neuroendocrine carcinoma; Surgery; Radiation therapy; Chemotherapy; Overall survival

摘要：Background Chemotherapy is regularly recommended for surgically rectal neuroendocrine carcinoma (NEC) patients. However, the additional benefit of perioperative radiotherapy for these patients is unclear to date. This study aims to evaluate the outcome of radiotherapy in rectal NECs who treated with surgery and chemotherapy. Methods This is a retrospective controlled study based on SEER database. Propensity score matching (PSM) was applied to reduce the baseline bias. Rectal NECs who underwent surgical resection plus chemotherapy with or without radiotherapy were extracted from SEER database. According to whether receiving radiotherapy, patients were divided into two cohorts: radiation treatment (RT) group and non-RT group. Overall survival (OS) was measured to assess the clinical benefits of RT. Kaplan-Meier survival analysis, univariable and multivariable regression analysis were applied. Results A total of 666 eligible patients were finally enrolled. The difference in OS remained significant both before and after PSM. Subgroup analyses revealed significantly better results for stage II, III and even IV patients who received radiotherapy whether before or after matching (all p < 0.05). The multivariable analysis showed that radiotherapy was associated with OS (HR 0.54; 95% CI 0.45 to 0.65; p < 0.001), together with distant metastasis. These results were consistent after matching (both p < 0.05). Conclusions Radiotherapy was an independent favorable prognostic factor for rectal NECs. The addition of radiotherapy to surgery plus chemotherapy might improve the clinical outcome. In the future, well-designed prospective studies are needed to assess the potential role of radiation in managing surgically resectable rectal NEC.