文献类型：期刊文献

中文题名：不同生物碱透皮吸收促进剂对芍药苷透皮吸收的影响

英文题名：Influences of different alkaloid penetration enhancers on transdermal absorption of paeoniflorin

作者：李芸[1];魏舒畅[1];刘永琦[1];闫治攀[1];颜春鲁[1];张九妹[1];侯桃霞[1]

第一作者：李芸

机构：[1]甘肃中医学院甘肃省高校中(藏)药化学与质量研究省级重点实验室,甘肃730000

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2014

卷号：37

期号：6

起止页码：410

中文期刊名：北京中医药大学学报

外文期刊名：Journal of Beijing University of Traditional Chinese Medicine

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：兰州市科技局项目(No.2009-2-11)

语种：中文

中文关键词：芍药苷;透皮吸收促进剂;吴茱萸总生物碱;芥子碱硫氰酸盐;盐酸小檗碱;小鼠

外文关键词：paeoniflorin ; penetration enhancers ; evodia rutaecarpa alkaloids ; sinapine thiocyanate ; berberine hydrochloride ; mice

摘要：目的考察吴茱萸总生物碱、芥子碱硫氰酸盐、盐酸小檗碱3种促进剂对芍药苷的体外透皮渗透效果,筛选有效的透皮促渗剂,提高芍药苷的透皮速率。方法以小鼠离体腹部皮肤为渗透屏障,采用HPLC法对芍药苷进行含量测定,考察3种促进剂在12 h内对芍药苷累积渗透量、透皮吸收速率、透皮时滞等体外透皮吸收动力学参数的影响。结果吴茱萸总生物碱、芥子碱硫氰酸盐、盐酸小檗碱的渗透速率分别为0.543 9、0.993 0、3.709 9 g/(cm^2·h),增渗倍数(ER)分别为1.50、2.74、10.22,透皮时滞分别为2.10、1.12、0.34 h。结论 3种天然透皮促进剂均能明显促进芍药苷的透皮吸收,为研究其透皮给药提供参考依据。
Objective alkaloids, sinapine thi To survey the effects of 3 kinds of penetration enhancers, evodia rutaecarpa ocyanate and berberine hydrochloride, on transdermal permeation of paeoniflorin in vitro, screen effective penetration enhancers and improve the transcutaneous permeability of paeoniflorin. Methods The abdomen skin of mice in vitro was taken as permeation barrier. The content of paeoniflorin was determined by using HPLC for studying the influences of 3 kinds of penetration enhancers on kinetic parameters of in vitro transdermal absorption of paeoniflorin including cumulative permeation quantity, transdermal absorption rate and transdermal time-lag within 12 h. Results The transcutaneous permeability of evodia rutaecarpa alkaloids, sinapine thiocyanate and berberine hydrochloride was, respectively, 0. 543 9 g/cm2 · h, 0. 993 0 g/cm2 · h and 3. 709 9 g/cm2 · h, enhancing rate was, respectively, 1.50, 2.74 and 10.22, and transdermal time-lag was, respectively, 2.10 h, 1.12 h and 0.34 h. Conclusion Evodia rutaecarpa alkaloids, sinapine thiocyanate and berberine hydrochloride can significantly improve the transdermal absorption of paeoniflorin.