文献类型：期刊文献

英文题名：Effect of da Vinci robot versus thoracoscopic surgery on lung function and oxidative stress levels in NSCLC patients: a propensity score-matched study

作者：Hong, Ziqiang[1,2];Liu, Qing[3];Li, Hongchao[1,2];Cui, Baiqiang[1,2];Cheng, Tao[1,2];Lu, Yingjie[1];Wu, Xusheng[1,2];Jin, Dacheng[2];Gou, Yunjiu[2];Dong, Xinchun[2]

第一作者：Hong, Ziqiang

通信作者：Gou, YJ[1];Dong, XC[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Thorac Surg, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ Second Hosp, Dept Thorac Surg, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Thorac Surg, Lanzhou 730000, Gansu, Peoples R China.

年份：2024

卷号：38

期号：2

起止页码：706

外文期刊名：SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

收录：;Scopus(收录号：2-s2.0-85178229680);WOS:【SCI-EXPANDED(收录号:WOS:001110383200001)】；

语种：英文

外文关键词：Robot-assisted thoracoscopic surgery; Video-assisted thoracoscopic surgery; Non-small cell lung cancer; Lung function; Oxidative stress; Propensity score matching analysis

摘要：Background To evaluate the short-term efficacy, lung function, and oxidative stress levels between the robotic-assisted thoracoscopic surgery (RATS) and video-assisted thoracoscopic surgery group (VATS) for non-small cell lung cancer (NSCLC).Methods We conducted a retrospective cohort study, selecting 248 NSCLC patients who underwent minimally invasive lobectomy at the Department of Thoracic Surgery, Gansu Provincial People's Hospital, from August 2019 to February 2023. There were 105 patients in the RATS group and 143 patients in the VATS group. The patients in the two groups were subjected to 1:1 propensity score matching analysis (PSM), and the perioperative indicators were recorded. The levels of oxidative stress factors (superoxide dismutase, SOD; malondialdehyde, MDA) and inflammatory factors were measured 1 day before surgery and 3 days after surgery, respectively. Pulmonary function and patient quality of life were measured at 1 day preoperatively and 3 months postoperatively.Results There are 93 patients in each group after PSM. Compared to the VATS group, the RATS group had shorter operation time, less intraoperative blood loss, greater number and groups of lymph nodes cleared, and shorter postoperative hospital stay. The SOD level in the RATS group was higher and the MDA level was lower than that in the VATS group after surgery. Postoperative inflammatory cytokine levels were less elevated in the RATS group than in the VATS group. At 3 months postoperatively, FVC%, FEV1%, and GQOLI-74 scores were higher in the RATS group than in the VATS group.Conclusion Compared to VATS lobectomy, RATS lobectomy has the advantages of shorter operative time, lesser bleeding, more lymph node dissection, faster postoperative recovery, and lesser impact on postoperative lung function. It is also capable of reducing the postoperative oxidative stress and inflammatory response, which can improve patients' quality of life.