详细信息
文献类型:期刊文献
中文题名:lncRNA PVT1在消化系统肿瘤中的研究进展
英文题名:Progress of lncRNA PVT1 in digestive system tumors
作者:史婷婷[1,2,3];张亚妮[1,2,3];伍杨[1,2,3];朱玲玲[1,2,3];张润兵[1,2,3];张久聪[1]
第一作者:史婷婷
机构:[1]中国人民解放军联勤保障部队第九四〇医院消化内科,甘肃兰州730050;[2]甘肃中医药大学第一临床医学院;[3]中国人民解放军联勤保障部队第九四〇医院基础医学实验室甘肃省干细胞与基因药物重点实验室
第一机构:中国人民解放军联勤保障部队第九四〇医院消化内科,甘肃兰州730050
年份:2025
卷号:34
期号:2
起止页码:277
中文期刊名:胃肠病学和肝病学杂志
外文期刊名:Chinese Journal of Gastroenterology and Hepatology
基金:甘肃省卫生健康行业科研计划项目(GSWSKY2023-34);甘肃中医药大学导师专项(2023YXKY020)。
语种:中文
中文关键词:消化系统肿瘤;lncRNA PVT1;作用机制
外文关键词:Digestive system tumors;LncRNA PVT1;Mechanism of action
摘要:消化系统肿瘤在我国高发,死亡率极高,严重威胁人体健康,成为目前亟待解决的临床难题。近几年研究发现长链非编码RNA(long non-coding RNA,lncRNA)在消化道肿瘤中发挥了重要作用,lncRNA人浆细胞瘤转化迁移基因1(plasmacytoma variant translocation 1,PVT1)是lncRNA的关键分子,参与了肿瘤细胞的增殖、迁移、侵袭、转化等过程。本文就lncRNA PVT1在消化道肿瘤中的作用和机制进行简要综述,以期为消化道肿瘤的诊断和治疗提供理论依据。
Digestive system tumors are highly prevalent in China,with a very high mortality rate,posing a serious threat to human health and becoming a clinical problem that needs to be solved urgently.In recent years,it has been found that long non-coding RNA(lncRNA)plays an important role in digestive tract tumors.LncRNA human plasmacytoma variant translocation 1(PVT1)is a key molecule of lncRNA,which is involved in the proliferation,migration,invasion and transformation of tumor cells.This paper provided a brief review on the role and mechanism of lncRNA PVT1 in digestive tract tumors,with a view to providing a theoretical basis for the diagnosis and treatment of digestive tract tumors.
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