文献类型：期刊文献

英文题名：Lipid dysregulation is associated with anxiety symptoms and left frontopolar cortical network alterations in overt hypothyroidism

作者：Cao, Jiancang[1,2];Zou, Quan[1];Liu, Xingqi[1];Wang, Xue[1];Ma, Wenxiu[1];Luo, Na[1];Yan, Xiangru[3];Huang, Gang[2];Zhao, Lianping[1,2,3]

第一作者：Cao, Jiancang

通信作者：Zhao, LP[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Radiol, 204 Donggang West Rd, Lanzhou 730000, Gansu Province, Peoples R China;[3]Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Radiol, 204 Donggang West Rd, Lanzhou 730000, Gansu Province, Peoples R China.

年份：2026

卷号：148

外文期刊名：PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

收录：;Scopus(收录号：2-s2.0-105043205800);WOS:【SCI-EXPANDED(收录号:WOS:001802960300001)】；

基金：This work was supported by the Key Research and Development Program of Gansu Province, China (Grant No. 23YFFA0048) ; the Gansu Provincial Health Commission Scientific Research Project (Grant No. GSWSQN2024-03) ; the Gansu Provincial Youth 'JiebangGuashuai' Project for Key Scientific and Technological Problems (Grant No. GQK2024032) ; and the Gansu Province In-Hospital Youth Fund Project (Grant No. 24GSSYB-5) .

语种：英文

外文关键词：Hypothyroidism; Lipid metabolism; Cortical network; Neuropsychiatric manifestations

摘要：Purpose Neuropsychiatric symptoms persist in overt hypothyroidism (OH) despite hormone replacement. This study examined whether cortical morphometric similarity network alterations are associated with lipid dysregulation and neuropsychiatric symptoms in OH. Methods We enrolled 87 treatment-na & iuml;ve OH patients and 87 matched healthy controls. Cortical morphometric similarity networks were constructed from T1-weighted magnetic resonance imaging (MRI) using Morphometric Inverse Divergence (MIND) across 360 regions. Mediation, spatial transcriptomic, and neurotransmitter mapping analyses were performed. Results OH patients exhibited reduced MIND strength in five cortical regions (false discovery rate [FDR]-corrected P < 0.05), most notably the left frontopolar area (L-10 pp; Cohen's d = -0.40), with connectivity disruptions across all seven canonical networks. Bootstrap mediation analyses (5000 resamples) identified L-10 pp as a significant indirect link between lipid markers and mood symptoms: four of five models showed robust indirect effects (95% confidence intervals [CIs] excluding zero), including triglycerides (TG) -> L-10 pp -> 24-item Hamilton Depression Rating Scale (HAMD-24) (0.086, [0.010, 0.148]) and high-density lipoprotein cholesterol (HDL-C) -> L-10 pp -> Hamilton Anxiety Rating Scale (HAMA) (-0.081, [-0.148, -0.005]). MIND alterations spatially correlated with serotonergic/monoaminergic systems (spin-test FDR-corrected P < 0.05) and were enriched in endothelial cell (normalized enrichment score [NES] = 2.097, P = 0.001), oligodendrocyte (NES = 1.806, P = 0.003), and microglia (NES = 1.575, P = 0.048) gene expression (all FDR-corrected). Conclusions In OH, lipid dysregulation is associated with mood symptoms, and mediation analysis identifies reduced structural integrity of L-10 pp as a plausible indirect link. The spatial pattern of MIND alterations corresponds to transcriptional profiles enriched in oligodendrocyte and endothelial cell genes.