文献类型：期刊文献

英文题名：Interruption of mitochondrial symbiosis is associated with the development of osteoporosis

作者：Zhang, Haoling[1,2,3];Zhao, Rui[4];Wang, Xuemei[5];Qi, Yaqian[4];Sandai, Doblin[2];Wang, Wei[6];Song, Zhijing[4,7];Liang, Qiudong[1]

第一作者：Zhang, Haoling;张虎林;张惠玲

通信作者：Liang, QD[1];Sandai, D[2];Song, ZJ[3];Wang, W[4];Song, ZJ[5]

机构：[1]Xinxiang Med Coll, Affiliated Hosp 1, Dept Spinal & Trauma Surg, Xinxiang, Henan, Peoples R China;[2]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Gelugor, Penang, Malaysia;[3]Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Peoples R China;[5]Gansu Univ Tradit Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[6]Gansu Univ Tradit Chinese Med, Coll Acupuncture & Massage, Lanzhou, Peoples R China;[7]Minist Educ, Key Lab Dunhuang Med & Transformat, Lanzhou, Peoples R China

第一机构：Xinxiang Med Coll, Affiliated Hosp 1, Dept Spinal & Trauma Surg, Xinxiang, Henan, Peoples R China

通信机构：[1]corresponding author), Xinxiang Med Coll, Affiliated Hosp 1, Dept Spinal & Trauma Surg, Xinxiang, Henan, Peoples R China;[2]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Gelugor, Penang, Malaysia;[3]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Peoples R China;[4]corresponding author), Gansu Univ Tradit Chinese Med, Coll Acupuncture & Massage, Lanzhou, Peoples R China;[5]corresponding author), Minist Educ, Key Lab Dunhuang Med & Transformat, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;Scopus(收录号：2-s2.0-85217848835);WOS:【SCI-EXPANDED(收录号:WOS:001421995900001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study is supported by National Natural Science Foundation of China, No.81960877; University Innovation Fund of Gansu Province, No.2021A-076; Gansu Province Science and Technology Plan (Innovation Base and Talent Plan), No. 21JR7RA561; Natural Science Foundation of Gansu Province and No. 21JR1RA267;Education Technology Innovation Project of Gansu Province, No.2022A-067; and Open Project of Key Laboratory of Dunhuang Medicine and Transformation of Ministry of Education, No.DHYX21-07, No. DHYX22-05, and No. DHYX21-01. This is also supported by Gansu Province Joint Fund General Program, No.24JRRA878; Gansu Provincial Science and Technology Program Project, No. 24JRRA1020; Gansu Province Key Talent Program, No. 2025RCXM006; Teaching Research and Reform Program for Postgraduate Education at Gansu University of Traditional Chinese Medicine (GUSTCM), No. YBXM-202406; and Special Fund for Mentors of "Qihuang Talents" in the First-Level Discipline of Chinese Medicine, No. ZYXKBD-202415 and ZYXKSD-202415.

语种：英文

外文关键词：interruption of mitochondrial endosymbiosis; osteoporosis; cytoplasmic signal; bone tissue cells; heredity; ADAPT; targeted therapy

摘要：Mitochondria maintain bacterial traits because of their endosymbiotic origins, yet the host cell recognizes them as non-threatening since the organelles are compartmentalized. Nevertheless, the controlled release of mitochondrial components into the cytoplasm can initiate cell death, activate innate immunity, and provoke inflammation. This selective interruption of endosymbiosis as early as 2 billion years ago allowed mitochondria to become intracellular signaling hubs. Recent studies have found that the interruption of mitochondrial symbiosis may be closely related to the occurrence of various diseases, especially osteoporosis (OP). OP is a systemic bone disease characterized by reduced bone mass, impaired bone microstructure, elevated bone fragility, and susceptibility to fracture. The interruption of intra-mitochondrial symbiosis affects the energy metabolism of bone cells, leads to the imbalance of bone formation and bone absorption, and promotes the occurrence of osteoporosis. In this paper, we reviewed the mechanism of mitochondrial intersymbiosis interruption in OP, discussed the relationship between mitochondrial intersymbiosis interruption and bone marrow mesenchymal stem cells, osteoblasts and osteoclasts, as well as the inheritance and adaptation in the evolutionary process, and prospected the future research direction to provide new ideas for clinical treatment.